|BRCA1 C Terminus (BRCT) domain|
Structure of an XRCC1 BRCT domain.
BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins.
The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage, for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.
Human proteins containing this domain include:
- BARD1; BRCA1
- CTDP1; DNTT
- MCPH1; MDC1
- PARP1; PARP4; PAXIP1; PES1
- REV1; RFC1; TOPBP1; TP53BP1; XRCC1
- Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17 (21): 6404–11. doi:10.1093/emboj/17.21.6404. PMC 1170965. PMID 9799248.
- Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF (1997). "A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins". FASEB J. 11 (1): 68–76. PMID 9034168.
- Yu X, Chini CC, He M, Mer G, Chen J (2003). "The BRCT domain is a phospho-protein binding domain". Science 302 (5645): 639–642. doi:10.1126/science.1088753. PMID 14576433.
- Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_1
- Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_2
- Eukaryotic Linear Motif resource motif class LIG_BRCT_MDC1_1
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