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Bromodomain containing 8
Symbols BRD8 ; SMAP; SMAP2; p120
External IDs OMIM602848 MGI1925906 HomoloGene41790 GeneCards: BRD8 Gene
RNA expression pattern
PBB GE BRD8 202227 s at tn.png
PBB GE BRD8 210352 at tn.png
More reference expression data
Species Human Mouse
Entrez 10902 78656
Ensembl ENSG00000112983 ENSMUSG00000003778
UniProt Q9H0E9 Q8R3B7
RefSeq (mRNA) NM_001164326 NM_001289606
RefSeq (protein) NP_001157798 NP_001276535
Location (UCSC) Chr 5:
137.48 – 137.51 Mb
Chr 18:
34.6 – 34.62 Mb
PubMed search [1] [2]

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.[1][2][3]

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.[3]


BRD8 has been shown to interact with Thyroid hormone receptor beta[2] and Retinoid X receptor alpha.[4]


  1. ^ Nielsen MS, Petersen CM, Gliemann J, Madsen P (Jun 1996). "Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain". Biochim Biophys Acta 1306 (1): 14–6. doi:10.1016/0167-4781(95)00239-1. PMID 8611617. 
  2. ^ a b Monden T, Wondisford FE, Hollenberg AN (Dec 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J Biol Chem 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056. 
  3. ^ a b "Entrez Gene: BRD8 bromodomain containing 8". 
  4. ^ Monden, T; Kishi M; Hosoya T; Satoh T; Wondisford F E; Hollenberg A N; Yamada M; Mori M (Oct 1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers". Mol. Endocrinol. (UNITED STATES) 13 (10): 1695–703. doi:10.1210/me.13.10.1695. ISSN 0888-8809. PMID 10517671. 

Further reading[edit]