BST1

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Bone marrow stromal cell antigen 1
Protein BST1 PDB 1isf.png
PDB rendering based on 1isf.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BST1 ; CD157
External IDs OMIM600387 MGI105370 HomoloGene3198 GeneCards: BST1 Gene
EC number 3.2.2.6
RNA expression pattern
PBB GE BST1 205715 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 683 12182
Ensembl ENSG00000109743 ENSMUSG00000029082
UniProt Q10588 Q64277
RefSeq (mRNA) NM_004334 NM_009763
RefSeq (protein) NP_004325 NP_033893
Location (UCSC) Chr 4:
15.7 – 15.74 Mb
Chr 5:
43.82 – 43.84 Mb
PubMed search [1] [2]

ADP-ribosyl cyclase 2 is an enzyme that in humans is encoded by the BST1 gene.[1][2]

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population.[2]

See also[edit]

References[edit]

  1. ^ Kaisho T, Ishikawa J, Oritani K, Inazawa J, Tomizawa H, Muraoka O, Ochi T, Hirano T (Jul 1994). "BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth". Proc Natl Acad Sci U S A 91 (12): 5325–9. doi:10.1073/pnas.91.12.5325. PMC 43987. PMID 8202488. 
  2. ^ a b "Entrez Gene: BST1 bone marrow stromal cell antigen 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.