BTLA

B and T lymphocyte associated
PDB rendering based on 2aw2.
Available structures PDB 2aw2
Identifiers
Symbols	BTLA; BTLA1; CD272; FLJ16065; MGC129743
External IDs	OMIM: 607925 MGI: 2658978 HomoloGene: 52233 GeneCards: BTLA Gene
Gene Ontology Molecular function • receptor activity Cellular component • plasma membrane • plasma membrane • integral to plasma membrane • external side of plasma membrane Biological process • immune response-regulating cell surface receptor signaling pathway • negative regulation of B cell proliferation • T cell costimulation • negative regulation of alpha-beta T cell proliferation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	151888	208154
Ensembl	ENSG00000186265	ENSMUSG00000052013
UniProt	Q7Z6A9	Q32MV8
RefSeq (mRNA)	NM_001085357.1	NM_001037719
RefSeq (protein)	NP_001078826.1	NP_001032808
Location (UCSC)	Chr 3: 112.18 – 112.22 Mb	Chr 16: 45.22 – 45.25 Mb
PubMed search	[1]	[2]

B- and T-lymphocyte attenuator is a protein that in humans is encoded by the BTLA gene. BTLA has also been designated as CD272 (cluster of differentiation 272).

Function

BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

Clinical significance

BTLA activation inhibits the function of human CD8⁺ cancer-specific T cells.

Further reading

• Pao LI, Bedzyk WD, Persin C, Cambier JC (1997). "Molecular targets of CD45 in B cell antigen receptor signal transduction". J. Immunol. 158 (3): 1116–24. PMID 9013950. 
• Pao LI, Cambier JC (1997). "Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells". J. Immunol. 158 (6): 2663–9. PMID 9058799. 
• Vilen BJ, Famiglietti SJ, Carbone AM, et al. (1997). "B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation". J. Immunol. 159 (1): 231–43. PMID 9200459. 
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16267. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gavrieli M, Watanabe N, Loftin SK, et al. (2004). "Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2". Biochem. Biophys. Res. Commun. 312 (4): 1236–43. doi:10.1016/j.bbrc.2003.11.070. PMID 14652006. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Sedy JR, Gavrieli M, Potter KG, et al. (2005). "B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator". Nat. Immunol. 6 (1): 90–8. doi:10.1038/ni1144. PMID 15568026. 
• Gonzalez LC, Loyet KM, Calemine-Fenaux J, et al. (2005). "A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator". Proc. Natl. Acad. Sci. U.S.A. 102 (4): 1116–21. doi:10.1073/pnas.0409071102. PMC 544343. PMID 15647361. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=544343. 
• Cheung TC, Humphreys IR, Potter KG, et al. (2005). "Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13218–23. doi:10.1073/pnas.0506172102. PMC 1201609. PMID 16131544. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1201609. 
• Compaan DM, Gonzalez LC, Tom I, et al. (2006). "Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex". J. Biol. Chem. 280 (47): 39553–61. doi:10.1074/jbc.M507629200. PMID 16169851. 
• Otsuki N, Kamimura Y, Hashiguchi M, Azuma M (2006). "Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells". Biochem. Biophys. Res. Commun. 344 (4): 1121–7. doi:10.1016/j.bbrc.2006.03.242. PMID 16643847. 
• Wang XF, Chen YJ, Wang Q, et al. (2007). "Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells". Tissue Antigens 69 (2): 145–53. doi:10.1111/j.1399-0039.2006.00710.x. PMID 17257317. 

External links

• MeSH BTLA+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.