Baccharis sergiloides is a species of baccharis known by the common name desert baccharis. It is native to the southwestern United States and northern Mexico, where it grows in wet areas in dry desert and woodland habitat, such as streambeds. This is a shrub producing many erect, branching stems approaching two meters in maximum height. The leaves are mostly oval shape and up to about 3 centimetres (1.2 in) long. The leaves generally fall by the time the plant blooms. The shrub is dioecious, with male and female plants producing flower heads of different types. The head is enclosed in a layer of phyllaries which are glandular and sticky. The fruit is a ribbed achene with a pappus a few millimeters long.