Human flora

From Wikipedia, the free encyclopedia

The human flora is the assemblage of microrganisms that constantly and consistently inhabit the human body. They include bacteria, fungi and archaea. Some of these organisms are known to perform tasks that are useful for the human host, while the majority have no known beneficial or harmful effect. Those that are expected to be present, and that under normal circumstances do not cause disease, are deemed members of the normal flora,^[1] or microbiota. An effort to better describe the microflora of humans has been initiated; see Human microbiome project.

[edit] The Bacterial Flora

It is estimated that 500 to 1000 species of bacteria live in the human gut^[2] and a roughly similar number on the skin.^[3][4] Bacterial cells are much smaller than human cells, and there are at least ten times as many bacteria as human cells in the body (approximately 10¹⁴ versus 10¹³).^[5][6] Though members of the flora are found on all surfaces exposed to the environment (on the skin and eyes, in the mouth, nose, small intestine), the vast majority of bacteria live in the large intestine.

Many of the bacteria in the digestive tract, collectively referred to as the gut flora, are able to break down certain nutrients such as carbohydrates that humans otherwise could not digest. The majority of these commensal bacteria are anaerobes, meaning they survive in an environment with no oxygen. Bacteria of the normal flora can act as opportunistic pathogens at times of lowered immunity.^[1]

Escherichia coli (a.k.a. E. coli) is a bacterium that lives in the colon; it is an extensively studied model organism and probably the best understood bacterium of all.^[7] Certain mutated strains of these gut bacteria do cause disease; an example is E. coli O157:H7.

A number of types of bacteria, such as Actinomyces viscosus and A. naeslundii, live in the mouth, where they are part of a sticky substance called plaque. If this is not removed by brushing, it hardens into calculus (also called tartar). The same bacteria also secrete acids that dissolve tooth enamel, causing tooth decay.

The vaginal microflora consist mostly of various lactobacillus species. It was long thought that the most common of these species was Lactobacillus acidophilus, but it has later been shown that the most common one is L. iners followed by L. crispatus. Other lactobacilli found in the vagina are L. delbruekii and L. gasseri. Disturbance of the vaginal flora can lead to bacterial vaginosis.

[edit] The Human Bacterial Flora and Human Health

Color-enhanced scanning electron micrograph showing Salmonella typhimurium (red) invading cultured human cells

Bacteria are vital for the maintenance of human health, but some pathogenic bacteria also pose a significant health threat by causing diseases. Large numbers of bacteria live on the skin and in the digestive tract. Their growth can be increased by warmth and sweat. Large populations of these organisms on humans are the cause of body odor and thought to play a part in acne. There are more than 500 bacterial species present in the normal human gut and are generally beneficial: they synthesize vitamins such as folic acid, vitamin K and biotin, and they ferment complex indigestible carbohydrates.^[8][9] Other beneficial bacteria in the normal flora include Lactobacillus species, which convert lactose and other sugars to lactic acid in the gut.^[10] The presence of such bacterial colonies also inhibits the growth of potentially pathogenic bacteria (usually through competitive exclusion) and some beneficial bacteria are consequently sold as probiotic dietary supplements.^[11]

[edit] The Archaean Flora

Archaea are present in the human gut, but in contrast to the enormous variety of bacteria in this organ, the number of archaeal species are much more limited.^[12] The dominant group is the methanogens, particularly Methanobrevibacter smithii and Methanosphaera stadtmanae.^[13] However, colonization by methanogens is variable and only about 50% of humans have easily-detectable populations of these organisms.^[14]

[edit] Archaea and Human Health

As of 2007, no clear examples of archaeal pathogens are known,^[15][16] although a relationship has been proposed between the presence of some methanogens and human periodontal disease.^[17]

[edit] The Fungal Flora

Fungi, particularly yeasts are present in the human gut. The best studied of these are Candida species. This is because of their ability to become pathogenic in immunocompromised hosts.^[18] Yeasts are also present on the skin, particularly Malassezia species, where they consume oils secreted from the sebaceous glands.^[19][20]

[edit] The Gut Flora

The gut flora is the human flora of microorganisms that normally live in the digestive tract and can perform a number of useful functions for their hosts. Though widely known as the "intestinal microflora", this is technically a misnomer since the word root "flora" pertains to plants and biota refers to microbial life such as bacteria other than plants. Thus recently, the more appropriate term "intestinal microbiota" is applied, though its use has not eclipsed the entrenched use and recognition of "flora" with regard to intestinal bacteria, and for the time being, both terms are being used in different textbooks.

The average human body, consisting of about 10¹³ (10,000,000,000,000 or about ten trillion) cells, has about ten times that number of microorganisms in the gut.^{[21][22][23][24]} There's an estimate of about 500 different bacterial species in the intestine.^[25] The metabolic activity performed by these bacteria is equal to that of a virtual organ making the gut bacteria termed as a "forgotten" organ.^[25]

Bacteria make up most of the flora in the colon^[26] and 60% of the dry mass of feces.^[23] This fact makes feces an ideal source to test for gut flora for any tests and experiments by extracting the nucleic acid from fecal specimens, and bacterial 16S rRNA gene sequences are generated with bacterial primers. This form of testing is ideal when compared to more invasive techniques, such as biopsies. Somewhere between 300^[23] and 1000 different species live in the gut,^[21] with most estimates at about 500.^[24][27] However, it is probable that 99% of the bacteria come from about 30 or 40 species.^[28] Fungi and protozoa also make up a part of the gut flora, but little is known about their activities.

Research suggests that the relationship between gut flora^[29] and humans is not merely commensal (a non-harmful coexistence), but rather is a mutualistic, symbiotic relationship.^[21] Though people can survive with no gut flora,^[24] the microorganisms perform a host of useful functions, such as fermenting unused energy substrates, training the immune system, preventing growth of harmful species,^[23] regulating the development of the gut, producing vitamins for the host (such as biotin and vitamin K), and producing hormones to direct the host to store fats. However, in certain conditions, some species are thought to be capable of causing disease by causing infection or increasing cancer risk for the host.^[23][26]

[edit] References

[edit] See also

• Microorganism
• Human microbiome project