Bactericidal/permeability-increasing protein (BPI) is a 456- residue (~50k Da) protein that is part of the innate immune system. [1 ]
Distribution and function [ edit ]
BPI was initially identified in
neutrophils, but is found in other tissues including the epithelial lining of mucous membranes. It is an endogenous antibiotic protein with potent killing activity against [2 ] Gram-negative bacteria. It binds to compounds called lipopolysaccharides produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the immune system; however, BPI at certain concentrations can prevent this activation.
BPI was discovered by Jerrold Weiss and Peter Elsbach at
New York University Medical School.
Because lipopolysaccharides are potent
inflammatory agents, and the action of antibiotics can result in the release of these compounds, the binding capacity of BPI was explored as a possible means of reducing injury. Xoma Ltd. developed a recombinant 25kDa portion of the BPI molecule called rBPI 21, NEUPREX, or opebecan. In a trial, it was found to decrease the mortality of Gram-negative bacterial-induced sepsis. Studies suggest that its binding activity is not the means by which it mediates its protective effect. [3 ] Studies show biological effects with [4 ] Gram-positive bacteria and even in infection by the [5 ] protozoan, . Toxoplasma gondii [6 ]
References [ edit ]
^ Elsbach, Peter (July 1, 1998). "The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense" (pdf). Journal of Leukocyte biology (USA: Wiley-Liss) 64 (1): 14–18. ISSN 0741-5400. PMID 9665269 . Retrieved . 2008-04-08
^ Geraldine Canny; Ofer Levy; Glenn T. Furuta; Sailaja Narravula-Alipati; Richard B. Sisson; Charles N. Serhan; Sean P. Colgan (2002-03-19). "Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia". PNAS (USA: National Academy of Sciences) 99 (6): 3902–3907. doi: 10.1073/pnas.052533799. ISSN 0027-8424. PMC 122621. PMID 11891303 . Retrieved . 2008-04-08
^ Michael Levin; Peter A Quint, Brahm Goldstein, Phil Barton, John S Bradley, SD Shemie, Timothy Yeh, Sun Sook Kim, Daniel P Cafaro, Patrick J Scannon and Brett P Giroir (September 16, 2000). "Recombinant bactericidal/permeability-increasing protein (rBPI. 21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial" Lancet (England: Lancet Publishing Group) 356 (9234): 961–967. doi: 10.1016/S0140-6736(00)02712-4. ISSN 0140-6736. PMID 11041396 . Retrieved . 2008-04-09 Lay summary – Business Wire (2000-09-14).
^ G Schlag; H Redl; J Davies; P Scannon (February 1999). "Protective effect of bactericidal/permeability-increasing protein (rBPI21) in baboon sepsis is related to its antibacterial, not antiendotoxin, properties". Annals of Surgery (US: Lippincott Williams & Wilkins) 229 (2): 262–271. doi: 10.1097/00000658-199902000-00015. ISSN 0003-4932. PMC 1191640. PMID 10024109.
^ Amit Srivastava; Heather Casey; Nathaniel Johnson; Ofer Levy; Richard Malley (January 2007). "Recombinant Bactericidal/Permeability-Increasing Protein rBPI21 Protects against Pneumococcal Disease". Infection and Immunity (US: American Society for Microbiology) 75 (1): 342–349. doi: 10.1128/IAI.01089-06. ISSN 0019-9567. PMC 1828387. PMID 17101667.
^ Anis A. Khan; Lewis H. Lambert Jr., Jack S. Remington, and Fausto G. Araujo (April 1, 1999). "Recombinant Bactericidal/Permeability-Increasing Protein (rBPI21) in Combination with Sulfadiazine Is Active against Toxoplasma gondii". Antimicrobial Agents and Chemotherapy (US: American Society for Microbiology) 43 (4): 758–762. ISSN 0066-4804. PMC 89203. PMID 10103177 . Retrieved . 2008-04-09
External links [ edit ]