Baicalin

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Not to be confused with baicalein.
Baicalin
Baicalin.svg
Identifiers
CAS number 21967-41-9 N
PubChem 64982
ChemSpider 58507 YesY
UNII 347Q89U4M5 YesY
ChEBI CHEBI:2981 YesY
ChEMBL CHEMBL485818 YesY
Jmol-3D images Image 1
Properties
Molecular formula C21H18O11
Molar mass 446.36 g mol−1
Melting point 202 to 205 °C (396 to 401 °F; 475 to 478 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Baicalin is a flavone, a type of flavonoid. It is found in several species in the genus Scutellaria, including Scutellaria lateriflora (blue skullcap). There are 10 mg/g baicalin in Scutellaria galericulata (common skullcap) leaves.[1] Baicalin is the glucuronide of baicalein.

It is a component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis) and one of the chemical ingredients of Sho-Saiko-To, an herbal supplement.

Baicalin is a known prolyl endopeptidase inhibitor,[2] induces apoptosis in pancreatic cancer cells,[3] and affects the GABA receptors.[citation needed]

References[edit]

  1. ^ P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979
  2. ^ Tarragó, T; Kichik, N; Claasen, B; Prades, R; Teixidó, M; Giralt, E (2008). "Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor". Bioorganic & medicinal chemistry 16 (15): 7516–24. doi:10.1016/j.bmc.2008.04.067. PMID 18650094. 
  3. ^ Takahashi H, Chen MC, Pham H, Angst E, King JC, Park J, Brovman EY, Ishiguro H, Harris DM, Reber HA, Hines OJ, Gukovskaya AS, Go VL, Eibl G (2011). "Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells". Biochim Biophys Acta 1813 (8): 1465–1474. doi:10.1016/j.bbamcr.2011.05.003. PMC 3123440. PMID 21596068.