Balsalazide

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Balsalazide
Balsalazide.png
Systematic (IUPAC) name
(E)-5-([4-(2-carboxyethylcarbamoyl)phenyl]diazenyl)-2-hydroxybenzoic acid
Clinical data
Trade names Colazal, Giazo
AHFS/Drugs.com monograph
MedlinePlus a699052
Pregnancy cat.
Legal status
Pharmacokinetic data
Bioavailability <1%
Protein binding ≥99%
Half-life 12hr
Identifiers
CAS number 80573-04-2 YesY
ATC code A07EC04
PubChem CID 5362070
DrugBank DB01014
ChemSpider 10662422 YesY
UNII P80AL8J7ZP YesY
ChEBI CHEBI:267413 YesY
ChEMBL CHEMBL1201346 N
Chemical data
Formula C17H15N3O6 
Mol. mass 357.318 g/mol
 N (what is this?)  (verify)

Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. It is sold under the brand names "Giazo", "Colazal" in the US and "Colazide" in the UK. It is also sold in generic form in the US by several generic manufacturers.

It is usually administered as the disodium salt. Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA,[1] in the large intestine. Its advantage over that drug in the treatment of ulcerative colitis is believed to be the delivery of the active agent past the small intestine to the large intestine, the active site of ulcerative colitis.

References[edit]

  1. ^ Kruis, W.; Schreiber, I.; Theuer, D.; Brandes, J. W.; Schütz, E.; Howaldt, S.; Krakamp, B.; Hämling, J.; Mönnikes, H.; Koop, I.; Stolte, M.; Pallant, D.; Ewald, U. (2001). "Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses". Gut 49 (6): 783–789. doi:10.1136/gut.49.6.783. PMC 1728533. PMID 11709512.  edit