Beginning at the intersection of 4th Street N (US 92 and SR 687 and 5th Avenue N in St. Petersburg, Florida, it runs west of US 19 near the Gulf coast passing through the cities of Seminole, Clearwater, Dunedin and Tarpon Springs before ending at US 19 in Holiday, Pasco County, Florida. It is also the unsigned State Road 595 throughout the entire route. It also runs along much of the Pinellas Trail.
U.S. Route 19 Business (US 19 Business) in Albany, Georgia is co-signed with US BUS 82 throughout its entire length. It begins at Exit 2B on the Liberty Expressway and joins westbound US BUS 82. From there US BUS 19/82 turn north at Georgia State Route 234, and joins a concurrency with that route until both business routes end at Exit 6 which is the west end of the US 19/82 overlap, and the east end of the US 82/GA 234 overlap.
U.S. Route 19 Business is a 3 miles (4.8 km) business route established in 1980 that replaced the original US 19 routing through the city of Murphy, along Hiwassee Street, Valley River Avenue, Hill Street, Andrews Road and Pleasant Valley Road.
U.S. Route 19 Connector (US 19 Conn) is a .72-mile (1.16 km) connector route established on October 2011, that connect US 19 (Main Street) with US 74 (Great Smoky Mountains Expressway). Also known as Veterans Boulevard, it was upgraded to primary status because of real need of maintenance and Swain County's secondary route budget was unable to support it. The route is an undivided four-lane the entire length and serves as the main entrance to Bryson City.
U.S. Route 19 Business (US 19 Bus), established in 1960, is a 2.3 miles (3.7 km) business route currently starts on Haywood Road then go north on I-26/I-240 (exit 2) back to the main US 19 (exit 3). Historically, US 19 Business continued along Haywood Road, connecting to Clingman Avenue and then to Patton Avenue/US 19. In 1961, it extended over Patton Avenue through downtown Asheville when US 19 moved onto the East-West Freeway. In 1962, it was rerouted to its current alignment from Haywood Road to Hanover Street (now I-26/I-240). It is co-signed with US 23 Bus.
U.S. Route 19 Business, established on September 1967, this 5.5 miles (8.9 km) business route follows the original US 19 mainline through the city of Weaverville. The business loop is clearly marked along the route, though the freeway bypass (I-26/US 19/US 23) does not mention it. It starts from exit 23 interchange (with a brief overlap with US 25), then goes north along Weaverville Road and Main Street; it reconnects with the freeway at the exit 18 interchange via Clarks Chapel Road/Monticello Road.
U.S. Route 19 Alternate was a former segment of US 19 that ran from Bayonte Point to Brooksville, Florida, which only existed for one year. It ran along what is today State Road 52 from Bayonet Point to Gowers Corner, and then turned north along US 41 into Brooksville.