Barakol

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Barakol
Barakol structure.png
Systematic (IUPAC) name
2,5-Dimethyl-3aH-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol
Clinical data
Legal status ?
Identifiers
CAS number 24506-68-1 N
ATC code None
PubChem CID 3080731
ChemSpider 2338470 YesY
Chemical data
Formula C13H12O4 
Mol. mass 232.231 g/mol
 N (what is this?)  (verify)

Barakol is a compound found in the plant Senna siamea,[1] which is used in traditional herbal medicine. It has sedative and anxiolytic effects,[2][3] but use for these purposes is now discouraged due to hepatotoxicity.[4]

References[edit]

  1. ^ Padumanonda, T.; Gritsanapan, W. (March 2006). "Barakol Contents in Fresh and Cooked Senna siamea Leaves". The Southeast Asian Journal of Tropical Medicine and Public Health 37 (2): 388–393. PMID 17125004. 
  2. ^ Thongsaard, W.; Pongsakorn, S.; Sudsuang, R.; Bennett, G. W.; Kendall, D. A.; Marsden, C. A. (January 1997). "Barakol, a Natural Anxiolytic, Inhibits Striatal Dopamine Release but Not Uptake in vitro". European Journal of Pharmacology 319 (2-3): 157–164. doi:10.1016/S0014-2999(96)00850-3. PMID 9042586. 
  3. ^ Sukma, M.; Chaichantipyuth, C.; Murakami, Y.; Tohda, M.; Matsumoto, K.; Watanabe, H. (November 2002). "CNS Inhibitory Effects of Barakol, a Constituent of Cassia siamia Lamk". Journal of Ethnopharmacology 83 (1-2): 87–94. doi:10.1016/S0378-8741(02)00206-4. PMID 12413711. 
  4. ^ Hongsirinirachorn, M.; Threeprasertsuk, S.; Chutaputti, A. (June 2003). "Acute Hepatitis Associated with Barakol". Journal of the Medical Association of Thailand = Chotmaihet Thangphaet. 86 Suppl. 2: S484–489. PMID 12930029.