Jackson, an alumnus of the University of North Carolina at Chapel Hill (bachelor's degree, 1984; law degree, 1990) and Duke University (LL.M. 2014), has worked as a legal counsel for the state of North Carolina for most of her legal career, working in the office of Governor James G. Martin (1991–1992), as an advocate for persons with disabilities (1992–1996), and as General Counsel to the North Carolina Department of Labor (2001–2004).
In 2004, Jackson was elected to an eight-year term on the North Carolina Court of Appeals, defeating incumbent judge Alan Thornburg in the statewide judicial elections. In 2010, Jackson was elected to a seat on the North Carolina Supreme Court that had been held by Edward Thomas Brady, who did not run for re-election. She defeated Robert C. Hunter, a colleague on the court of appeals, in the statewide judicial elections to win the seat. When she took office in January 2011, Jackson became the court's 96th associate justice and formed a 4-3 majority of female justices for the first time in the court's history.