The following year Pino became ill. His brother Francesco (Cecco) was suspected of poisoning him, but the Forlivese lord survived. Cecco was in the end assassinated, and Pino could be the sole lord of the city, maintaining that position thanks the support of Venice.
However, when Barbara suddenly died, Pino was accused by Astorre of poisoning her. The magnificent sepulchre that her husband commissioned her (now in the Abbey of San Mercuriale in Forlì) was seen as a proof of his guilty conscience. It was the first tomb in Romagna designed on Renaissance principles.