Base J

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β-Anomer of Glucopyranosyloxymethyluracil
Biosynthesis of the base J = D-glucopyranosyloxymethyluracil with A: Thymidine hydroxylase; B: beta-glucosyltranferase; 1: dT (desoxy thymidine); 2: HOCH3dU; 3: dJ

Beta-d-glucopyranosyloxymethyluracil or Base J is a hypermodified base found in the DNA of kinetoplastids including the human pathogenic Trypanosomes. Base J is formed by the initial hydroxylation of thymidine and the subsequent glycosylation by an as yet unidentified glycosyltransferase.[1]

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