Bcl-2-interacting killer

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BCL2-interacting killer (apoptosis-inducing)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BIK ; BIP1; BP4; NBK
External IDs OMIM603392 MGI1206591 HomoloGene924 GeneCards: BIK Gene
Species Human Mouse
Entrez 638 12124
Ensembl ENSG00000100290 ENSMUSG00000016758
UniProt Q13323 O70337
RefSeq (mRNA) NM_001197 NM_007546
RefSeq (protein) NP_001188 NP_031572
Location (UCSC) Chr 22:
43.51 – 43.53 Mb
Chr 15:
83.53 – 83.54 Mb
PubMed search [1] [2]

Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene.[1][2][3]


The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.[3]


Bcl-2-interacting killer has been shown to interact with BCL2-like 1[4][5][6][7] and Bcl-2.[5][6]


  1. ^ Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ et al. (Dec 1995). "Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins". Oncogene 11 (9): 1921–8. PMID 7478623. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ a b "Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)". 
  4. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ a b Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG et al. (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. 
  6. ^ a b Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B et al. (July 2003). "Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway". EMBO J. 22 (14): 3580–90. doi:10.1093/emboj/cdg343. PMC 165613. PMID 12853473. 
  7. ^ Jiang A, Clark EA (May 2001). "Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis". J. Immunol. 166 (10): 6025–33. doi:10.4049/jimmunol.166.10.6025. PMID 11342619. 

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