Bcl-2-interacting killer
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| BCL2-interacting killer (apoptosis-inducing) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | BIK; BIP1; BP4; NBK | ||||||||||||
| External IDs | OMIM: 603392 MGI: 1206591 HomoloGene: 924 GeneCards: BIK Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 638 | 12124 | |||||||||||
| Ensembl | ENSG00000100290 | ENSMUSG00000016758 | |||||||||||
| UniProt | Q13323 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001197 | NM_007546.2 | |||||||||||
| RefSeq (protein) | NP_001188 | NP_031572.1 | |||||||||||
| Location (UCSC) | Chr 22: 43.51 – 43.53 Mb |
Chr 15: 83.36 – 83.38 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene.[1][2][3]
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.[3]
[edit] Interactions
Bcl-2-interacting killer has been shown to interact with BCL2-like 1[4][5][6][7] and Bcl-2.[5][6]
[edit] References
- ^ Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ, et al. (Dec 1995). "Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins". Oncogene 11 (9): 1921–8. PMID 7478623.
- ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- ^ a b "Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=638.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ^ a b Chen, Lin; Willis Simon N, Wei Andrew, Smith Brian J, Fletcher Jamie I, Hinds Mark G, Colman Peter M, Day Catherine L, Adams Jerry M, Huang David C S (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell (United States) 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. ISSN 1097-2765. PMID 15694340.
- ^ a b Gillissen, Bernhard; Essmann Frank, Graupner Vilma, Stärck Lilian, Radetzki Silke, Dörken Bernd, Schulze-Osthoff Klaus, Daniel Peter T (July 2003). "Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway". EMBO J. (England) 22 (14): 3580–90. doi:10.1093/emboj/cdg343. ISSN 0261-4189. PMC 165613. PMID 12853473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=165613.
- ^ Jiang, A; Clark E A (May 2001). "Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis". J. Immunol. (United States) 166 (10): 6025–33. ISSN 0022-1767. PMID 11342619.
[edit] Further reading
- Chittenden T, Flemington C, Houghton AB, et al. (1996). "A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.". EMBO J. 14 (22): 5589–96. PMC 394673. PMID 8521816. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=394673.
- Han J, Sabbatini P, White E (1996). "Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K.". Mol. Cell. Biol. 16 (10): 5857–64. PMC 231587. PMID 8816500. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231587.
- Inohara N, Ding L, Chen S, Núñez G (1997). "harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L).". EMBO J. 16 (7): 1686–94. doi:10.1093/emboj/16.7.1686. PMC 1169772. PMID 9130713. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169772.
- Huang DC, Adams JM, Cory S (1998). "The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4.". EMBO J. 17 (4): 1029–39. doi:10.1093/emboj/17.4.1029. PMC 1170452. PMID 9463381. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170452.
- Hegde R, Srinivasula SM, Ahmad M, et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.". J. Biol. Chem. 273 (14): 7783–6. doi:10.1074/jbc.273.14.7783. PMID 9525867.
- Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
- Holmgreen SP, Huang DC, Adams JM, Cory S (1999). "Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members.". Cell Death Differ. 6 (6): 525–32. doi:10.1038/sj.cdd.4400519. PMID 10381646.
- Castells A, Ino Y, Louis DN, et al. (1999). "Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer.". Gastroenterology 117 (4): 831–7. doi:10.1016/S0016-5085(99)70341-0. PMID 10500065.
- Verma S, Budarf ML, Emanuel BS, Chinnadurai G (2000). "Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences.". Gene 254 (1–2): 157–62. doi:10.1016/S0378-1119(00)00276-6. PMID 10974546.
- Jiang A, Clark EA (2001). "Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis". J. Immunol. 166 (10): 6025–33. PMID 11342619.
- Federici M, Hribal M, Perego L, et al. (2001). "High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program". Diabetes 50 (6): 1290–301. doi:10.2337/diabetes.50.6.1290. PMID 11375329.
- Zou Y, Peng H, Zhou B, et al. (2002). "Systemic tumor suppression by the proapoptotic gene bik". Cancer Res. 62 (1): 8–12. PMID 11782349.
- Germain M, Mathai JP, Shore GC (2002). "BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria". J. Biol. Chem. 277 (20): 18053–60. doi:10.1074/jbc.M201235200. PMID 11884414.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gillissen B, Essmann F, Graupner V, et al. (2003). "Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway". EMBO J. 22 (14): 3580–90. doi:10.1093/emboj/cdg343. PMC 165613. PMID 12853473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=165613.
- Arena V, Martini M, Luongo M, et al. (2003). "Mutations of the BIK gene in human peripheral B-cell lymphomas". Genes Chromosomes Cancer 38 (1): 91–6. doi:10.1002/gcc.10245. PMID 12874789.
- Hur J, Chesnes J, Coser KR, et al. (2004). "The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2351–6. doi:10.1073/pnas.0307337101. PMC 356954. PMID 14983013. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=356954.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604.
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