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Clinical data
Trade names Nulojix
AHFS/ Consumer Drug Information
MedlinePlus a606016
Licence data US FDA:link
Pregnancy cat.
Legal status
Routes Intravenous
CAS number  YesY
ATC code L04AA28
Chemical data
Formula ?
 N (what is this?)  (verify)

Belatacept (trade name Nulojix) is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4,[1] which is a molecule crucial for T-cell costimulation, selectively blocking the process of T-cell activation. It is intended to provide extended graft survival while limiting the toxicity generated by standard immune suppressing regimens, such as calcineurin inhibitors. It differs from abatacept (Orencia) by only 2 amino acids.

Belatacept was developed by Bristol-Myers-Squibb and approved by the U.S. Food and Drug Administration on June 15, 2011.[2]


  1. ^ " CTLA-4 Strategies". Archived from the original on 5 December 2008. Retrieved 2008-10-24. 
  2. ^ "FDA approves Nulojix for kidney transplant patients" (Press release). U.S. Food and Drug Administration. 2011-06-15. Archived from the original on 19 June 2011. Retrieved 2011-06-16.