Collecting duct carcinoma
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Position of the papillary duct in the kidney
Collecting duct carcinoma (CDC) (also known as Bellini duct carcinoma, low-grade collecting duct carcinoma and tubulocystic carcinoma) is a type of kidney cancer that originates in the papillary duct of the kidney. It is rare, accounting for 1-3% of all kidney cancers. It is also recently described; a 2002 review found just 40 case reports worldwide. Previously, due to its location, CDC was commonly diagnosed as renal cell carcinoma or a subtype of renal cell carcinoma. However, CDC does not respond well to chemotherapy drugs used for renal cell carcinoma, and progresses and spreads more quickly. One small study reporting 20% survival at 2 years. CDC may be related to urothelial carcinoma aka transitional cell carcinoma, and case reports of treating CDC as for transitional cell carcinoma indicate some benefit.
CDC is extremely rare, and thus hard to study. Currently, very few published works compare histopathological and clinical data. Because of this, there is no standard protocol for its diagnosis and treatment.
This cancer has a distinctive "bubble wrap" appearance. It has been reported to occur together with urothelial carcinoma of the bladder, and a cancer with intermediate histology also has been reported, leading to the suspicion that these cancers are related.
Signs and symptoms
Signs and symptoms are as for kidney cancer.
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