Collecting duct carcinoma

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Papillary duct
Position of the papillary duct in the kidney
Latin ductus papillaris
Gray's p.1223
Anatomical terminology

Collecting duct carcinoma (CDC) (also known as Bellini duct carcinoma, low-grade collecting duct carcinoma[1] and tubulocystic carcinoma[1]) is a type of kidney cancer that originates in the papillary duct of the kidney. It is rare, accounting for 1-3% of all kidney cancers.[2] It is also recently described; a 2002 review found just 40 case reports worldwide.[3] Previously, due to its location, CDC was commonly diagnosed as renal cell carcinoma or a subtype of renal cell carcinoma.[4] However, CDC does not respond well to chemotherapy drugs used for renal cell carcinoma, and progresses and spreads more quickly. One small study reporting 20% survival at 2 years.[4] CDC may be related to urothelial carcinoma aka transitional cell carcinoma, and case reports of treating CDC as for transitional cell carcinoma indicate some benefit.

CDC is extremely rare, and thus hard to study. Currently, very few published works compare histopathological and clinical data. Because of this, there is no standard protocol for its diagnosis and treatment.


This cancer has a distinctive "bubble wrap" appearance.[1] It has been reported to occur together with urothelial carcinoma of the bladder,[5][6] and a cancer with intermediate histology also has been reported,[7] leading to the suspicion that these cancers are related.[6]

Signs and symptoms[edit]

Signs and symptoms are as for kidney cancer.


CDC was thought to be renal cell carcinoma, until "recently developed techniques of lectin histochemistry" helped forward knowledge of kidney duct cancers.[8]


  1. ^ a b c Amin MB, MacLennan GT, Gupta R, Grignon D, Paraf F, Vieillefond A, Paner GP, Stovsky M, Young AN, Srigley JR, Cheville JC (March 2009). "Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma". Am. J. Surg. Pathol. 33 (3): 384–92. doi:10.1097/PAS.0b013e3181872d3f. PMID 19011562. 
  2. ^ Fakhrai N, Haitel A, Balassy C, Zielinski CC, Schmidinger M (January 2005). "Major response and clinical benefit following third-line treatment for Bellini duct carcinoma". Wien. Klin. Wochenschr. 117 (1–2): 63–5. doi:10.1007/s00508-004-0289-4. PMID 15986594. 
  3. ^ Singh I, Nabi G (2002). "Bellini duct carcinoma: review of diagnosis and management". Int Urol Nephrol 34 (1): 91–5. doi:10.1023/A:1021315130481. PMID 12549647. 
  4. ^ a b Méjean A, Rouprêt M, Larousserie F, Hopirtean V, Thiounn N, Dufour B (April 2003). "Is there a place for radical nephrectomy in the presence of metastatic collecting duct (Bellini) carcinoma?". J. Urol. 169 (4): 1287–90. doi:10.1097/01.ju.0000050221.51509.f5. PMID 12629344. 
  5. ^ Hsiao HL, Yeh HC, Chang TH, Ke HL, Lin HC, Wu WJ, Huang CH, Lee YC (March 2008). "Renal collecting duct carcinoma and concomitant bladder urothelial carcinoma: a case report". Kaohsiung J. Med. Sci. 24 (3): 157–62. doi:10.1016/S1607-551X(08)70144-X. PMID 18364277. 
  6. ^ a b Okuda H, Tei N, Shimizu K, Imazu T, Yoshimura K, Kiyohara H, Nakamura Y, Fujimura H (October 2008). "[Case report: collecting (Bellini) duct carcinoma during the follow-up for bladder cancer]". Hinyokika Kiyo (in Japanese) 54 (10): 665–8. PMID 19048932. 
  7. ^ Maestroni U, Ferretti S, Dinale F, Froio E, Pilato FP, Ciuffreda M, Mellissari M, Cortellini P (2006). "A renal cancer with intermediate characteristics between collecting (Bellini) duct carcinoma and urothelial carcinoma: case report and review of the literature". Tumori 92 (6): 545–8. PMID 17260499. 
  8. ^ O Natsume, S Ozono, T Futami, and M Ohta (1997). "Bellini duct carcinoma: a case report". Japanese Journal of Clinical Oncology 27 (2): 107–110. doi:10.1093/jjco/27.2.107. PMID 9152800. Retrieved 2008-06-03.