Belotecan
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| Systematic (IUPAC) name | |
| (4S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 256411-32-2 |
| ATC code | None |
| PubChem | CID 6456014 |
| ChemSpider | 4958253  |
| UNII | 27Z82M2G1N |
| Chemical data | |
| Formula | C25H27N3O4 |
| Mol. mass | 433.50 g/mol |
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Belotecan is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.
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