Browder appeared as a recurring guest on the U.S. television show Party of Five as Sam Brody in its 3rd season in 1997. Browder and Buller moved with their two children to Australia during the production of Farscape (1999–2003), on which Browder starred as American astronaut John Crichton. Buller played several guest roles on the show. The two returned to the United States in 2003 following the cancellation of Farscape. He has received two Saturn Awards for Best Actor in a Television Role for his acting in Farscape. He appeared in the 2004 movie A Killer Within, co-starring C. Thomas Howell and Sean Young. Also in 2004, he portrayed fellow actor Lee Majors in the made-for-TV film Behind the Camera: The Unauthorized Story of Charlie's Angels.
Browder returned to the SciFi Channel as he joined the cast of Stargate SG-1 for its ninth season in 2005. He played the character of Lieutenant Colonel Cameron Mitchell, the new commanding officer of SG-1. Browder's former Farscape co-star Claudia Black appeared on SG-1 in the eighth season episode entitled "Prometheus Unbound" and again during the first episodes of the ninth season before becoming a regular cast member on the series at the beginning of its tenth season in 2006. Several episodes of Stargate SG-1, most notably "200", comically alluded to Farscape during Browder and Black's time on the series.