Benign fibrous histiocytomas (also known as "Dermal dendrocytoma,"[1] "Dermatofibroma,"[2] "Fibrous dermatofibroma,"[2] "Fibrous histiocytoma"[2]:668, "Fibroma simplex",[1] "Nodular subepidermal fibrosis",[1] and "Sclerosing hemangioma"[1]) are benign skin growths.[3]
[edit] Presentation
Dermatofibromas are hard papules (rounded bumps) that may appear in a variety of colors, usually brownish to tan. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.[4] They are composed of disordered collagen laid down by fibroblasts. In rare cases, basal cell carcinoma may develop in a dermatofibroma.
They are usually found on the leg.[5]
Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.[6]
Dermatofibromas occur most often in women; the male to female ratio is about 1:4.[4]
[edit] Immunohistochemical staining
[edit] See also
[edit] References
- ^ a b c d e Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ^ a b c Freedberg, et. al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
- ^ "benign fibrous histiocytoma" at Dorland's Medical Dictionary
- ^ a b Pierson, Joseph C.; Diane M Pierson. "Dermatofibroma". eMedicine. WebMD. http://emedicine.medscape.com/article/1056742-overview. Retrieved 2009-06-13.
- ^ "dermatofibroma" at Dorland's Medical Dictionary
- ^ Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M (June 2006). "High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Archives of pathology & laboratory medicine 130 (6): 831–4. doi:10.1043/1543-2165(2006)130[831:HPAEDR]2.0.CO;2. PMID 16740036. http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=130&page=831.
- ^ Kim HJ, Lee JY, Kim SH, et al. (August 2007). "Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34". Br. J. Dermatol. 157 (2): 319–24. doi:10.1111/j.1365-2133.2007.08033.x. PMID 17596171.
- ^ http://emedicine.medscape.com/article/1056742-overview
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Diseases of the skin and appendages by morphology
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| Rashes |
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With
epidermal
involvement
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Without
epidermal
involvement
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Red
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Generalized
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Localized
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Specialized
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Nonblanchable
Purpura
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Indurated
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Miscellaneous
disorders |
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| Dermis |
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Subcutaneous
tumors |
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Connective and
vascular
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Other
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