Dicyclomine, also known as dicycloverine, is an anticholinergic that blocks muscarinic receptors. Dicycloverine was first synthesized in the United States circa 1947.
Medical uses 
10mg oral capsule of Dicyclomine Hydrochloride, manufactured by Mylan.
Dicyclomine is used to treat intestinal hypermotility and the symptoms of irritable bowel syndrome (IBS) (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.
In the UK it is an ingredient of a multi-ingredient preparation, together with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon.
It is also marketed as Meftal-SPAS containing mefenamic acid along with dicyclomine hydrochloride as an analgesic and antispasmodic.
Dicycloverine/dicyclomine has been used as an active placebo in animals and humans in studies of morphine and other narcotic analgesics; scopolamine, orphenadrine, and trihexyphenidyl have also been utilised as such over the years.
Side effects 
Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects. Recreational use of this drug for its anticholinergic effects has been rarely reported. Like other strong anticholinergics, three separate types of use in manners inconsistent with the labelling are seen, with apparently very little overlap -- dangerously high doses as a deliriant, therapeutic or elevated doses for anticholinergic euphoria, and therapeutic to elevated doses to enhance the effects of opioid analgesics; the latter two cases may overlap somewhat with a fourth category, that of the drug being used in therapeutic doses for the increase in sex drive it produces, a property it has in common with trihexyphenidyl (Artane, octane, Sexy Trihexy) and benztropine (Cogentin) as well as others. The range between the euphoriant and deliriant doses is rather large.
Breastfeeding is not recommended while using this drug. Users should use care when operating vehicles and/or dangerous machines.
- Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
- Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4
External links 
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