From Wikipedia, the free encyclopedia
Jump to: navigation, search
Abbreviations BIT
CAS number 2634-33-5 YesY
PubChem 17520
ChemSpider 16567 YesY
MeSH 1,2-benzisothiazoline-3-one
ChEBI CHEBI:167099 YesY
Jmol-3D images Image 1
Molecular formula C7H5NOS
Molar mass 151.19 g mol−1
Appearance white powder
Melting point 158 °C (316 °F; 431 K)[1]
Solubility in water 1 g/l
R-phrases R22, R38, R41, R43, R50 [1]
S-phrases (S2), S24, S26, S37/39, S61 [1]
Main hazards Xn, N [1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Benzisothiazolinone (BIT) is a widely used biocide and belongs to the group of isothiazolinones.


Benzisothiazolinone has a microbicide and a fungicide mode of action. It is widely used as a preservative, for example in:

  • emulsion paints, caulks, varnishes, adhesives, inks, and photographic processing solutions
  • home cleaning and car care products; laundry detergents, stain removers and fabric softeners;
  • industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins
  • agriculture in pesticide formulations
  • gas and oil drilling in muds and packer fluids preservation.[2]:iv

In paints, it is commonly used as a mixture with methylisothiazolinone. Typical concentrations in products are 200–400 ppm depending on the application area and the combination with other biocides. According to a study in Switzerland, 19% of the paints, varnishes and coatings contained BIT in 2000. The fraction in adhesives, sealants, plasters and fillers was 25%. [3]

Health hazards[edit]

It is a known human immune system toxicant, and also is classified as irritant for skin, eyes and lungs.[4] It is widely used as active ingredient of many home cleaning products.


  1. ^ a b c d Record of 1,2-Benzisothiazol-3(2H)-one in the GESTIS Substance Database from the IFA, accessed on 22 October 2007
  2. ^ US EPA. September 29, 2005 EPA Reregistration Decision
  3. ^ Reinhard et al.: "Preservation of products with MCI/MI in Switzerland". Contact Dermatitis. 2001 Nov;45(5):257-64. PMID 11722483
  4. ^ EWG's Skin Deep Cosmetics Database


  • Wilfried Paulus: Directory of Microbicides for the Protection of Materials and Processes. Springer Netherland, Berlin 2006, ISBN 1-4020-4861-0.