Benzylpenicilloyl polylysine

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Benzylpenicilloyl polylysine (structural diagram).png
Systematic (IUPAC) name
[2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate : L-Lysine homopolymer
Clinical data
Licence data US FDA:link
Legal status ?
Routes Liquid intradermal
CAS number 31855-75-1 N
ATC code None
DrugBank DB00895
Synonyms Pre-Pen
Chemical data
Formula ?
 N (what is this?)  (verify)

Benzylpenicilloyl polylysine (Pre-Pen) is used as a skin test before the administration of penicillin. It is used to detect the immunoglobulin E antibodies.[1][2] The chemical structure consists of the benzylpenicilloyl group attached to a polymer of L-lysine.[3][4][5]


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  3. ^ Vemuri, Preeti; Harris, Kathleen E.; Suh, Lydia A.; Grammer, Leslie C. (2004). "Preparation of benzylpenicilloyl-polylysine: a preliminary study". Allergy and Asthma Proceedings 25 (3): 165–168. 
  4. ^ Goldschmidt, BM; BB Levine (1983). "The preparation and determination of structure of benzylpenicilloyl compounds used in skin-testing for penicillin allergy.". Journal of Antibiotics 36 (6): 709–14. doi:10.7164/antibiotics.36.709. PMID 6874593. 
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