Benzylthiouracil

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Benzylthiouracil
Benzylthiouracil.svg
Systematic (IUPAC) name
1-(1-cyclohexa-2,4-dienylmethyl)-7-thia-
3,5-diazabicyclo[4.1.0]hepta-3,5-dien-2-one
Clinical data
AHFS/Drugs.com International Drug Names
Oral
Pharmacokinetic data
Excretion Renal
Identifiers
6336-50-1 YesY
H03BA03
PubChem CID 685814
ChemSpider 597542 YesY
UNII PZ35LUM333 YesY
ChEMBL CHEMBL1491306
Chemical data
Formula C11H10N2OS
218.276 g/mol
 YesY (what is this?)  (verify)

Benzylthiouracil (BTU) is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.

Adverse effects[edit]

Benzylthiouracil has been associated with severe adverse effects, notably vasculitis and subsequent ANCA-positive glomerulonephritis, as well as isolated reports of lung damage.[1][2][3][4]

References[edit]

  1. ^ Tieulie N, Huong DL, Andreu M et al. (2002). "[ANCA associated glomerulonephritis related to benzylthiouracil]". Rev Med Interne (in French) 23 (10): 853–6. doi:10.1016/S0248-8663(02)00694-X. PMID 12428489. 
  2. ^ Kaaroud H, Khiari K, Ben Moussa F, Barbouch S, Boussema E, Ben Maïz H (2002). "[Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease]". Rev Med Interne (in French) 23 (10): 857–61. doi:10.1016/S0248-8663(02)00704-X. PMID 12428490. 
  3. ^ Braham A, Houman MH, Rais L, Ben Gborbel I, Lamloum M, Miled M (2004). "[Benzylthiouracil induced ANCA-positive vasculitis]". Presse Médicale (in French) 33 (19 Pt 1): 1331–3. doi:10.1016/S0755-4982(04)98919-1. PMID 15615240. 
  4. ^ Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS (2006). "ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil". Eur J Pediatr 165 (7): 435–6. doi:10.1007/s00431-005-0053-4. PMID 16622664.