Bepridil
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| Systematic (IUPAC) name | |
| N-benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline | |
| Clinical data | |
| Trade names | Vascor |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a699051 |
| Pregnancy cat. | C (US) |
| Legal status | ? |
| Routes | Oral |
| Pharmacokinetic data | |
| Bioavailability | Well absorbed |
| Protein binding | 99% |
| Metabolism | Hepatic, CYP3A4-mediated |
| Half-life | 42 hours |
| Excretion | Renal |
| Identifiers | |
| CAS number | 64706-54-3  |
| ATC code | C08EA02 |
| PubChem | CID 2351 |
| DrugBank | APRD00727 |
| ChemSpider | 2261 |
| UNII | 755BO701MA |
| ChEBI | CHEBI:3061 |
| ChEMBL | CHEMBL1008 |
| Chemical data | |
| Formula | C24H34N2O |
| Mol. mass | 366.54 g/mol |
| SMILES | eMolecules & PubChem |
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Bepridil (trade name Vascor) is a calcium channel blocker once used to treat angina. It is no longer sold in the United States.
It is nonselective.[1]
It has been discussed as a possible option in the treatment of atrial fibrillation.[2]
It has been implicated in causing the ventricular arrythmia (Torsade de pointes).
[edit] References
- ^ Bezprozvanny I, Tsien RW (September 1995). "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Mol. Pharmacol. 48 (3): 540–9. PMID 7565636. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7565636.
- ^ Imai S, Saito F, Takase H, et al. (May 2008). "Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm" ([dead link]). Circ. J. 72 (5): 709–15. doi:10.1253/circj.72.709. PMID 18441448. http://joi.jlc.jst.go.jp/JST.JSTAGE/circj/72.709?from=PubMed.
[edit] External links
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