He is based in New York City where he operates apartment buildings and built several landmark buildings around the city including The Corinthian which was the largest individual apartment building in New York City when it was built. Spitzer is father of former New York Governor Eliot Spitzer. In 2008 he has an estimated net worth of $500 million.
Spitzer's parents, Morris and Molly, moved from Tulste, Poland (now Ukraine) to New York's Lower East Side after World War I. They operated a print shop. Bernard received an engineering degree from City College of New York in 1943 at the age of 18. He successfully competed with Jerry Stiller for the hand of Anne Goldhaber, whom they courted in the Catskills.
Real estate developer
Among the buildings Spitzer has built are:
- 1020 Park Avenue (1962), a 20 story co-op apartment at East 85th Street and Park Avenue
- 1050 Fifth Avenue (1958), a 20 story residential building at East 86th Street and Fifth Avenue
- 200 Central Park South (1963) - A 35 story residential building at Seventh Avenue and Central Park that is noted for its curved walls and a driveway that angles across the front of the building (other buildings along Central Park South are square)
- 210 Central Park South (1966), a 24 story residential building next door to 200 Central Park South
- 985 Fifth Avenue (1968), a 25-story residential building on the site of the Isaac Vail Brokaw Mansion
- 220 East 72nd Street (1974), a 28-story mixed use residential-institutional building—the first five of which are occupied by Marymount Manhattan College (where Anne taught)
- 800 Fifth Avenue (1978), a 34 story rental apartment building at 61st Street
- The Corinthian (New York) (1988), a 1 million sf, 57 story 1,100,000-square-foot (100,000 m2) building occupying an entire block  between 37th and 38th on First Avenue
- 150 East 57th Street (2000), a 34-story residential building
His New York buildings are leased by his subsidiary Urbana Properties, created in 2005.
Additionally, Spitzer has purchased several prominent commercial properties over the years, including:
- 730 Fifth Avenue (The Crown Building or Heckscher Building), New York City, - a 25 floor neo-classical office building completed in 1921 by Warren & Wetmore and acquired in 1991 for $95 million.
- 2001 K Street (William P. Rogers Building), NW, Washington, D.C. - 11 floor commercial and retail building completed in 2000 for $69 million and acquired in 2001 for $95 million.
- 1615 L Street, NW, Washington, D.C. - 13 floor post-modern glass curtain wall commercial building completed in 1984 and acquired in 2009 for $180 million.
- 4800 Hampden Lane (One Bethesda Center), Bethesda, Maryland - 13 floor commercial and retail comple completed in 1986 and acquired in 2011 for $90 million.
- 350 West Broadway, New York, NY - 11,000 sf, 2-story, retail property acquired in 2013.
- Anne and Bernard Spitzer Hall of Human Origins at the American Museum of Natural History
- Anne and Bernard Spitzer Chair in Political Science at the City University of New York
- Anne and Bernard Spitzer School of Architecture at the City College of City University of New York
- The Spitzer Family Program Fund for U.S. Health Policy at Princeton University
Father of the governor
Spitzer played a major role in the childhood and the rise to power of his son Eliot, the future New York Governor. According to biographers, during a game of Monopoly between father and son, the elder Spitzer would order his seven or eight year-old son, Eliot, to sell him a piece of property, which, later in the game, the future governor could not afford. In this way the father taught his son: "Never defer to authority."
To support Eliot's foray into politics, Bernard made a loan to his son of $5 million during the first two campaigns and by paying him $200,000 a year. At the time of the writing of this article, the Bernard and Anne Spitzer Charitable Trust donated at least $140,000 to organizations led by political allies.
In 2007 Governor Spitzer appointed Dale Hemmerdinger president of the Metropolitan Transportation Authority. Before being confirmed for that position, Hemmerdinger had to resign from the all-white, mostly Jewish Harmonie Club. It was then revealed that Bernard had been a member of the club for more than 30 years.
Also in August 2007, Republican strategist Roger Stone was accused of leaving this message on Bernard's office answering machine during the "Troopergate" scandal in which Eliot was accused of using state troopers to spy on Joseph Bruno:
- This is a message for Bernard Spitzer. You will be subpoenaed to testify before the Senate committee on investigations on your shady campaign loans. You will be compelled by the Senate sergeant at arms. If you resist this subpoena, you will be arrested and brought to Albany.
- And there‘s not a goddamn thing your phony, psycho, piece-of-shit son can do about it.
- Bernie, your phony loans are about to catch up with you. You will be forced to tell the truth. And the fact that your son's a pathological liar will be known to all." 
Stone initially denied involvement but eventually resigned as a consultant to the New York State Senate Republican Campaign Committee, at the request of Senate Majority Leader Joseph Bruno.
- "Disgraced NY Governor Won't Need New Job" at the Wayback Machine (archived March 21, 2008). Forbes. Associated Press. March 12, 2008.
- THE CITY COLLEGE OF NEW YORK APPOINTS DR. RANDALL C. FORSBERG FIRST HOLDER OF ANNE AND BERNARD SPITZER CHAIR IN POLITICAL SCIENCE cuny.edu - December 7, 2006
- Spoiling for a Fight: The Rise of Eliot Spitzer by Brooke A. Masters - Times Books - 2006 ISBN 0-8050-7961-0
- Bernard Spitzer - Emporis.com
- Luxury rental is underway - new condominium building to rise in East 57th St., New York, NY Real Estate Weekly, Oct 15, 1997
- Anne and Bernard Spitzer Hall of Human Origins amnh.org
- Was Spitzer Destined to Fall? - Time Magazine - March 13, 2008
- Helping hand from dad - Newsday - February 15, 2006
- Spitzer's Father Is Member of Harmonie - New York Sun - October 26, 2007
- 'Hardball with Chris Matthews' for August 22 - August 23, 2007 - msnbc.com