A former school friend of comedy writer Alan Simpson, Vertue was invited to join what was soon to become "Associated London Scripts" as a secretary-cum-girl Friday. She later found that she had become an agent, almost by stealth at ALS, representing comedy writers Spike Milligan, Eric Sykes, Johnny Speight, Ray Galton and Alan Simpson and Terry Nation (for whom she famously negotiated to partially keep his rights to his Dalek creation for Doctor Who). She also represented comedians Tony Hancock (until 1961) and Frankie Howerd.
In 1967 she joined the Stigwood Organisation, which had absorbed ALS, specialising in selling British television formats to America. These successes included Steptoe and Son, which became in the US Sanford and Son, and Til Death Us Do Part, which was turned into All in the Family.
In the 1980s Vertue formed Hartswood Films, which has produced many comedies including Men Behaving Badly, Is It Legal? and Coupling. The latter was produced by her daughter Sue Vertue and written by son-in-law Steven Moffat. She also served as executive producer of their dramatic series Sherlock.
Vertue received the OBE for services to television in the 2000 New Year Honours and in 2004 she received the British Academy Television Awards (BAFTA) Alan Clarke Award for Outstanding Creative Contribution to Television.
On 20 March 2012 she was given a Lifetime Achievement Award at the Royal Television Society Programme Awards, and on 30 March 2012 - she was presented with the Harvey Lee Award for Outstanding Contribution to Broadcasting at the BPG TV and Radio Awards.
On 25 January 2013 Vertue was the guest on BBC Radio 4's Desert Island Discs. Her musical choices were Elton John-Pinball Wizard; Giacomo Puccini-Nessun Dorma; Glenn Miller-Moonlight Serenade; Bee Gees-Morning of my Life; Broadway cast from Chorus Line - Finale; Elaine Paige-Don't Cry for Me Argentina from Evita; The London Session Orchestra-SHERlocked; Louis Armstrong-What a Wonderful World.
- "Beryl Vertue OBE - Producer and Chairman". Hartswood Films. 2012. Retrieved 9 January 2012.
- "Beryl Vertue". BBC Press Office. 2012. Retrieved 9 January 2012.
- BBC Radio 4. Desert Island Discs. January 2013, Beryl Vertue.