The film follows Ira's mentally handicapped cousin, Philly Wohl, who at that time was 52 years old and still living with his elderly parents. Ira forces his aunt and uncle to realize that they will not be around to care for Philly forever, and that they must start making preparations for when that time should come. Philly then begins to attend classes in New York City to learn how to take care of himself and become independent.
Philly's father, Max Wohl, dies during the course of the film. His mother, Pearl, died in 1980. Philly is now an octogenarian, and he lives in a group home where he has learned to basically take care of himself.
A sequel entitled Best Man: 'Best Boy' and All of Us, 20 Years Later, was produced in 1997. Following the sequel, in 2006, Ira made 'Best Sister' which rounded off the trilogy by looking at the effect Philly's sister had on his current life.