The structure of beta-glucosidase A from bacterium Clostridium cellulovorans.
|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / EGO|
Beta-glucosidase is a glucosidase enzyme located in on the brush border of the small intestine that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose). It is one of the cellulases, enzymes involved in the decomposition of cellulose and related polysaccharides; more specifically, an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.
Synonyms, derivatives, and related enzymes include gentiobiase, cellobiase, emulsin, elaterase, aryl-beta-glucosidase, beta-D-glucosidase, beta-glucoside glucohydrolase, arbutinase, amygdalinase, p-nitrophenyl beta-glucosidase, primeverosidase, amygdalase, linamarase, salicilinase, and beta-1,6-glucosidase.
Cellulose is largely composed of polymers of beta-bond linked glucose molecules, and beta-glucosidases are required by organisms (some fungi, bacteria) that can consume it. These enzymes are a powerful tool for degradation of plant cell walls for pathogens.
Lysozyme, an enzyme secreted in tears to prevent bacterial infection of the eye, is also a beta-glucosidase that cleaves β1→4 bonds between N-acetylglucosamine and N-acetylmuramic acid sugars within the peptidoglycan cell walls of gram-negative bacteria.
|glucosidase, beta, acid 3 (cytosolic)|
|Alt. symbols||CBGL1, KLRP|
|Locus||Chr. 4 p15.31|
- PDB 3AHX; Jeng, W.-Y., Wang, N.-C., Lin, M.-H., Lin, C.-T., Liaw, Y.-C., Chang, W.-J., Liu, C.-I., Liang, P.-H., Wang, A.H.-J. (August 2010). "Structural and functional analysis of three beta-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis.". J.Struc.Biol. 173 (1): 46–56. doi:10.1016/j.jsb.2010.07.008. PMID 20682343.; rendered via PyMOL.
- Cox, Michael; Lehninger, Albert L; Nelson, David R. (2000). Lehninger principles of biochemistry. New York: Worth Publishers. pp. 306–308. ISBN 1-57259-931-6.
- Amygdalin beta-glucosidase
- Prunasin beta-glucosidase
- Vicianin beta-glucosidase
- Glucosylceramidase, a related enzyme
- Cellulase, a suite of enzymes produced chiefly by fungi, bacteria, and protozoans that catalyze cellulolysis (i.e. the hydrolysis of cellulose)
- beta-Glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH)
- GO-database listing 'GO:0016162 cellulose 1,4-beta-cellobiosidase activity'
- Risk Assessment Summary, CEPA 1999. Trichoderma reesei P59G
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