β-Lactamase inhibitor

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A β-lactamase inhibitor (or beta-lactamase inhibitor) is a molecule used in conjunction with a β-Lactam antibiotic to extend its spectrum of activity.

Although β-lactamase inhibitors have little antibiotic activity of their own,[1] they instead inhibit the activity of β-lactamases, a family of enzymes that break the beta-lactam ring that allows penicillin-like antibiotics to work, thereby conferring bacterial resistance.

Some bacteria can produce extended spectrum β-lactamases (ESBLs) making the infection more difficult to treat and conferring additional resistance to penicillins, cephalosporins, and carbapenems.[2]

Commonly used agents[edit]

Beta-lactamase producing bacteria[edit]

Bacteria that can produce beta-lactamases include, but are not limited to:

References[edit]

  1. ^ "Beta-Lactamase Inhibitors". Department of Nursing of the Fort Hays State University College of Health and Life Sciences. October 2000. Archived from the original on 2007-09-27. Retrieved 2007-08-17. 
  2. ^ Livermore, D. M. (1995). "β-Lactamases in Laboratory and Clinical Resistance" (pdf). Clinical Microbiology Review 8 (4): 557–584. PMC 172876. PMID 8665470. 

External links[edit]