TGFBR3

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Transforming growth factor, beta receptor III
Identifiers
Symbols TGFBR3 ; BGCAN; betaglycan
External IDs OMIM600742 MGI104637 HomoloGene2436 GeneCards: TGFBR3 Gene
RNA expression pattern
PBB GE TGFBR3 204731 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7049 21814
Ensembl ENSG00000069702 ENSMUSG00000029287
UniProt Q03167 O88393
RefSeq (mRNA) NM_001195683 NM_011578
RefSeq (protein) NP_001182612 NP_035708
Location (UCSC) Chr 1:
92.15 – 92.37 Mb
Chr 5:
107.11 – 107.29 Mb
PubMed search [1] [2]

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors.[1][2]

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References[edit]

  1. ^ Andres JL, Stanley K. et al. (1989). "Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta". J. Cell Biol. 109 (6 (Pt 1)): 3137–3145. doi:10.1083/jcb.109.6.3137. PMC 2115961. PMID 2592419. 
  2. ^ Andres JL, DeFalcis D. et al. (1992). "Binding of two growth factor families to separate domains of the proteoglycan betaglycan". J. Biol. Chem. 267 (9): 5927–5930. PMID 1556106. 

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