Interferon beta-1b
| Systematic (IUPAC) name | |
|---|---|
| Human interferon beta | |
| Clinical data | |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| MedlinePlus | a601151 |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 145155-23-3  |
| ATC code | L03AB08 |
| DrugBank | BTD00078 |
| KEGG | D00746  |
| ChEMBL | CHEMBL1201563 |
| Chemical data | |
| Formula | C908H1408N246O253S6 |
| Mol. mass | 20011.0 g/mol |
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Interferon beta-1b (tradenames Betaferon, Betaseron (North America), Extavia and ZIFERON) is a drug in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS). It is approved for use after the first MS event. It is administered by sub-cutaneous injection and has been shown to slow the advance of the affliction as well as reduce the frequency of attacks.
It is believed that interferon-beta based drugs achieve their beneficial effect on MS progress via their anti-inflammatory properties. Studies have also determined that interferon-beta improves the integrity of the blood-brain barrier (BBB)—which generally breaks down in MS patients, allowing increasing amounts of undesirable substances to reach the brain. This strengthening of the BBB may be a contributing factor to interferon-beta's beneficial effects. These studies were carried out in vitro, so it does not necessarily mean it works the same in people.
Patients taking Interferon beta-1b may develop neutralizing antibodies to the medication.[1] Reference link
Betaferon/Betaseron is marketed today by Bayer HealthCare. The originator was Schering AG (Berlex in North America), now part of Bayer HealthCare. Novartis has also introduced Extavia, a new brand of interferon beta-1b, in 2009.
In 2010 ZIFERON (a new brand for interferon beta-1b) has also been brought in by Zistdaru Danesh Ltd.
Closely related is interferon beta-1a, also indicated for MS, and with a very similar drug profile.
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