Bezlotoxumab

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Bezlotoxumab ?
Monoclonal antibody
Source Human
Target Clostridium difficile
Clinical data
Legal status ?
Identifiers
CAS number 1245634-25-6
ATC code None
Chemical data
Formula C6464H9974N1726O2014S46 
Mol. mass 145.6 kDa

Bezlotoxumab is a human monoclonal antibody designed for the prevention of recurrence of Clostridium difficile infection.[1]

This drug, along with actoxumab, was developed through Phase II efficacy trials by a partnership between Medarex Inc and MassBiologics of the University of Massachusetts Medical School.[2] The project was then licensed to Merck Sharp & Dohme Corp for further development and commercialization.[3]

References[edit]

  1. ^ "Statement On A Nonproprietary Name Adopted By The USAN Council - Bezlotoxumab". American Medical Association. 
  2. ^ Lowy I, Molrine DC, Leav BA, Blair BM, Baxter R, Gerding DN, Nichol G, Thomas WD, Leney M, Sloan S, Hay CA, Ambrosino DM (January 2010). "Treatment with monoclonal antibodies against Clostridium difficile toxins". N. Engl. J. Med. 362 (3): 197–205. doi:10.1056/NEJMoa0907635. PMID 20089970. 
  3. ^ "Merck & Co., Inc., Medarex, Inc. and Massachusetts Biologic Laboratories Sign Exclusive Licensing Agreement for Investigational Monoclonal Antibody Combination for Clostridium Difficile Infection". Press Release. Merck Sharp & Dohme Corp.