Binedaline

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Binedaline
Binedaline.png
Systematic (IUPAC) name
N,N,N-trimethyl-N-(3-phenylindol-1-yl)ethane-1,2-diamine
Clinical data
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 60662-16-0 N
ATC code None
PubChem CID 42509
ChemSpider 38769 YesY
UNII 3AVG9P140R YesY
ChEMBL CHEMBL2104611 N
Chemical data
Formula C19H24ClN3 
Mol. mass 329.86696 g/mol
 N (what is this?)  (verify)

Binedaline (Ixprim), also called binodaline, is a drug that was being investigated as an antidepressant in the 1980s but never marketed.[1][2] It acts as a selective norepinephrine reuptake inhibitor (Ki = 25 nM), with relatively insignificant influence on the serotonin (Ki = 847 nM) and dopamine (Ki >= 2 µM) transporters.[3] It has negligible affinity for the α-adrenergic, mACh, H1, or 5-HT2 receptors.[3]

References[edit]

  1. ^ Faltus; Geerling, F. (1984). "A controlled double-blind study comparing binedaline and imipramine in the treatment of endogenous depression". Neuropsychobiology 12 (1): 34–38. doi:10.1159/000118107. PMID 6239991.  edit
  2. ^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
  3. ^ a b Morin; Zini, R.; Urien, S.; Tillement, J. P. (1989). "Pharmacological profile of binedaline, a new antidepressant drug". The Journal of Pharmacology and Experimental Therapeutics 249 (1): 288–296. PMID 2540319.  edit