Binospirone

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Binospirone
Binospirone.svg
Binospirone 3D.gif
Systematic (IUPAC) name
8-[2-(2,3-dihydro-1,4-benzodioxin-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione
Clinical data
Legal status ?
Identifiers
CAS number 124756-23-6
ATC code None
PubChem CID 60769
ChemSpider 54766
UNII T3M5D109V5 YesY
ChEMBL CHEMBL1487115
Chemical data
Formula C20H26N2O4 
Mol. mass 358.431 g/mol
 YesY (what is this?)  (verify)

Binospirone (MDL-73,005-EF) is a drug which acts as a partial agonist at 5-HT1A somatodendritic autoreceptors but as an antagonist at postsynaptic 5-HT1A receptors.[1] It has anxiolytic effects.[2]

See also[edit]

References[edit]

  1. ^ Bertrand, F; Lehmann, O; Galani, R; Lazarus, C; Jeltsch, H; Cassel, JC (2001). "Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats". Pharmacology, Biochemistry, and Behavior 68 (4): 647–60. doi:10.1016/S0091-3057(01)00448-8. PMID 11526961. 
  2. ^ Moser, PC; Tricklebank, MD; Middlemiss, DN; Mir, AK; Hibert, MF; Fozard, JR (1990). "Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam". British Journal of Pharmacology 99 (2): 343–9. doi:10.1111/j.1476-5381.1990.tb14706.x. PMC 1917389. PMID 1970269.