Bioceramic

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Bioceramics and bioglasses are ceramic materials that are biocompatible.[1] Bioceramics are an important subset of biomaterials.[2][3] Bioceramics range in biocompatibility from the ceramic oxides, which are inert in the body, to the other extreme of resorbable materials, which are eventually replaced by the materials which they were used to repair. Bioceramics are used in many types of medical procedures. A primary medical procedures where they are used is implants.[2] This article is primarily concerned with rigid materials commonly used as surgical implants, though some bioceramics are flexible. The ceramic materials used are not the same as porcelain type ceramic materials. Rather bioceramics are closely related to either the body's own materials, or are extremely durable metal oxides.

History[edit]

Prior to 1925 the materials used in implant surgery were primarily relatively pure metals. However these are not considered to be ceramics and are therefore outside the scope of this article. The success of these materials was surprising considering the relatively primitive surgical techniques. The 1930s marked the beginning of the era of better surgical techniques and also the first use of alloys such as Vitallium.

In 1969 L. L. Hench and others discovered that various kinds of glasses and ceramics could bond to living bone[4][5] Hench was inspired with the idea on his way to a conference on materials. He was seated next to a colonel who had just returned from the Vietnam War. The colonel shared that after an injury the bodies of soldiers would often reject the implant. Hench was intrigued and began to investigate materials that would be biocompatible. The final product was a new material which he called Bioglass. This work inspired a new field called bioceramics.[6] With the discovery of bioglass interest in bioceramics grew rapidly.

On April 26, 1988, the first international symposium on bioceramics was held in Kyoto, Japan.

Applications[edit]

A titanium hip prosthesis, with a ceramic head and polyethylene acetabular cup

Ceramics are now commonly used in the medical fields as dental, and bone implants.[7][8] Artificial teeth, and bones are relatively commonplace. Surgical cermets are used regularly. Joint replacements are commonly coated with bioceramic materials to reduce wear and inflammatory response. Other examples of medical uses for bioceramics are in pacemakers, kidney dialysis machines, and respirators.[6] The global demand on medical ceramics and ceramic components was about US$9.8 billion in 2010. It is forecast to have an annual growth of 6–7% in the following years, and the world market value will increase to US$15.3 billion by 2015 and reach US$18.5 billion by 2018.[9]

Future trends[edit]

One proposed use for bioceramics is the treatment of cancer. Two methods of treatment have been proposed; treatment through hyperthermia, and radiotherapy. Hyperthermia treatment involves implanting a bioceramic material that contains a ferrite or other magnetic material. The area is then exposed to alternating magnetic field, which causes the implant and surrounding area to heat up. Alternatively the bioceramic materials can be doped with β-emitting materials and implanted into the cancerous area.[2]

Other trends include engineering the materials for specific tasks. Ongoing research involves the chemistry, composition, and micro and nanostructures of the materials to improve their biocompatibility.[10][11][12]

Bioceramic materials[edit]

Bioceramic materials are commonly subdivided by their bioactivity. Bioinert materials are non-toxic and non-inflammatory. These materials must be long lasting, structural failure resistant, and corrosion resistant. Bioceramics additionally must have a low Young's modulus to help prevent cracking of the material.

Bioinert[edit]

Bioactive[edit]

See also[edit]

References[edit]

  1. ^ P. Ducheyne, G. W. Hastings (editors) (1984) CRC metal and ceramic biomaterials vol 1 ISBN 0-8493-6261-X
  2. ^ a b c J. F. Shackelford (editor)(1999) MSF bioceramics applications of ceramic and glass materials in medicine ISBN 0-87849-822-2
  3. ^ H. Oonishi, H. Aoki, K. Sawai (editors) (1988) Bioceramics vol. 1 ISBN 0-912791-82-9
  4. ^ Hench, Larry L. (1991). "Bioceramics: From Concept to Clinic". Journal of the American Ceramic Society 74 (7): 1487. doi:10.1111/j.1151-2916.1991.tb07132.x. 
  5. ^ T. Yamamuro, L. L. Hench, J. Wilson (editors) (1990) CRC Handbook of bioactive ceramics vol II ISBN 0-8493-3242-7
  6. ^ a b Kassinger, Ruth. Ceramics: From Magic Pots to Man-Made Bones. Brookfield, CT: Twenty-First Century Books, 2003, ISBN 978-0761325857
  7. ^ D. Muster (editor) (1992) Biomaterials hard tissue repair and replacement ISBN 0-444-88350-9
  8. ^ Kinnari, Teemu J.; Esteban, Jaime; Gomez-Barrena, Enrique; Zamora, Nieves; Fernandez-Roblas, Ricardo; Nieto, Alejandra; Doadrio, Juan C.; López-Noriega, Adolfo; Ruiz-Hernández, Eduardo; Arcos, Daniel; Vallet-Regí, María (2008). "Bacterial adherence to SiO2-based multifunctional bioceramics". Journal of Biomedical Materials Research Part A. doi:10.1002/jbm.a.31943. 
  9. ^ Market Report: World Medical Ceramics Market. Acmite Market Intelligence. 2011. 
  10. ^ Chai, Chou; Leong, Kam W (2007). "Biomaterials Approach to Expand and Direct Differentiation of Stem Cells". Molecular Therapy 15 (3): 467–80. doi:10.1038/sj.mt.6300084. PMC 2365728. PMID 17264853. 
  11. ^ Zhu, Xiaolong; Chen, Jun; Scheideler, Lutz; Altebaeumer, Thomas; Geis-Gerstorfer, Juergen; Kern, Dieter (2004). "Cellular Reactions of Osteoblasts to Micron- and Submicron-Scale Porous Structures of Titanium Surfaces". Cells Tissues Organs 178 (1): 13–22. doi:10.1159/000081089. PMID 15550756. 
  12. ^ Hao, L; Lawrence, J; Chian, KS (2005). "Osteoblast cell adhesion on a laser modified zirconia based bioceramic". Journal of Materials Science: Materials in Medicine 16 (8): 719–26. doi:10.1007/s10856-005-2608-3. PMID 15965741. 
  13. ^ O'Donnell, M. D.; Watts, S. J.; Hill, R. G.; Law, R. V. (2009). "The effect of phosphate content on the bioactivity of soda-lime-phosphosilicate glasses". Journal of Materials Science: Materials in Medicine 20 (8): 1611–8. doi:10.1007/s10856-009-3732-2. PMID 19330429. 
  14. ^ O'Donnell, M. D.; Watts, S. J.; Law, R. V.; Hill, R. G. (2008). "Effect of P2O5 content in two series of soda lime phosphosilicate glasses on structure and properties – Part I: NMR". Journal of Non-Crystalline Solids 354 (30): 3554. Bibcode:2008JNCS..354.3554O. doi:10.1016/j.jnoncrysol.2008.03.034. 
  15. ^ O'Donnell, M. D.; Watts, S. J.; Law, R. V.; Hill, R. G. (2008). "Effect of P2O5 content in two series of soda lime phosphosilicate glasses on structure and properties – Part II: Physical properties". Journal of Non-Crystalline Solids 354 (30): 3561. Bibcode:2008JNCS..354.3561O. doi:10.1016/j.jnoncrysol.2008.03.035.