Biochanin A is an O-methylated isoflavone. It is a natural organic compound in the class of phytochemicals known as flavonoids. Biochanin A can be found in red clover in [1 ] soy, in alfalfa sprouts, in peanuts, in chickpea ( Cicer arietinum) and in other legumes.
Biochanin A is classified as a
phytoestrogen and has putative benefits in dietary cancer prophylaxis. It has also been found to inhibit fatty acid amide hydrolase and to act as agonist of [2 ] PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2. [3 ]
Metabolism [ edit ]
biochanin-A reductase uses dihydrobiochanin A and NADP + to produce biochanin A, NADPH, and H +.
isoflavone-7-O-beta-glucoside 6"-O-malonyltransferase uses malonyl-CoA and biochanin A 7-O-β-D- glucoside to produce CoA and biochanin A 7-O-(6-O- malonyl-β-D-glucoside).
References [ edit ]
^ Medjakovic, S.; Jungbauer, A. (2008). "Red clover isoflavones biochanin A and formononetin are potent ligands of the human aryl hydrocarbon receptor". The Journal of Steroid Biochemistry and Molecular Biology 108 (1–2): 171–177. doi: 10.1016/j.jsbmb.2007.10.001. PMID 18060767.
^ Thors, L.; Burston, J. J.; Alter, B. J.; McKinney, M. K.; Cravatt, B. F.; Ross, R. A.; Pertwee, R. G.; Gereau, R. W. 4th; Wiley, J. L.; Fowler, C. J. (2010). "Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase" (pdf). British Journal of Pharmacology 160 (3): 549–560. doi: 10.1111/j.1476-5381.2010.00716.x. PMC 2931556. PMID 20590565.
^ Wang L, Waltenberger B, Pferschy-Wenzig EM, Blunder M, Liu X, Malainer C, Blazevic T, Schwaiger S, Rollinger JM, Heiss EH, Schuster D, Kopp B, Bauer R, Stuppner H, Dirsch VM, Atanasov AG. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochem Pharmacol. 2014 Jul 29. pii: S0006-2952(14)00424-9. doi: 10.1016/j.bcp.2014.07.018. PubMed PMID: 25083916.
See also [ edit ]
Note: The above list contains only
some known CB 1R agonists, as too many exist to list here completely. Refer here instead for more.
2-AGE (noladin ether)