Biological passport

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Not to be confused with a biometric passport.

An athlete biological passport is an individual, electronic record for professional athletes, in which profiles of biological markers of doping and results of doping tests are collated over a period of time. Doping violations can be detected by noting variances from an athlete’s established levels outside permissible limits, rather than testing for and identifying illegal substances.[1]

Although the terminology athlete passport is recent, the use of biological markers of doping has a long history in anti-doping. Maybe the first marker of doping, that tries to detect a prohibited substance not based on its presence in urine or blood, but through the induced deviations in biological parameters, is the so-called testosterone over epitestosterone ratio (T/E). The T/E has been used by sports authorities since the beginning of the 1980s to detect anabolic steroids in urine samples. A decade later, in 1997, markers of blood doping were introduced by some international federations, such as the Union Cycliste Internationale (UCI) and the Federation Internationale de Ski, to deter the abuse of recombinant erythropoietin that was undetectable by direct means at that time. It is only in 2002 that the paradigm to use biological markers of doping took the terminology athlete passport. The merits of this testing paradigm were exposed in the scientific literature [2] and the terminology adopted by the World Anti-Doping agency.[3]

Many believe[who?] that the athlete passport provides an excellent alternative to ensure fairness in elite sports. While a new drug test must be developed and validated for each new drug, the main advantage of the athlete passport is that it is based on the stability of the physiology of the human being. New drugs are produced at an unprecedented pace today and there is often a lag of several years between the availability of a new drug and the application of an effective detection method. In contrast, the physiology of the human being remains the same through several generations and all biomarkers developed today in the athlete passport will remain valid for at least several decades. For example, the blood module of the passport is already sensitive today to any new future form of recombinant erythropoietin, as well as to any form of gene doping that will enhance oxygen transfer to the muscles. Also, while a negative drug test does not necessarily mean that the athlete did not dope, the athlete can present his/her passport at the beginning of a competition to attest that he/she will compete in his/her natural, unaltered condition.

The athlete passport received a lot of attention when its blood module was established at the beginning of the 2008 racing season by the UCI.[4] In May 2008 they revealed that 23 riders were under suspicion of doping following the first phase of blood tests conducted under the new biological passport.[5] The blood module of the athlete passport aims to detect any form of blood doping, the steroid module any form of doping with anabolic steroid and the endocrine module any modification of the growth hormone/IGF-1 axis. Each of these modules are however at different steps of development, validation and application in sports.

Athlete biological passport testing[edit]

According to the World Anti-Doping Agency, the athlete biological passport is administered to establish whether an athlete is manipulating his/her physiological variables without detecting a particular substance or method. The biological passport uses the standardized approach of urine sampling to determine steroid abuse. The objective of this testing is to identify athletes in a haematological module and a steroidal module.

The haematological module tests for certain markers in the body that identify the enhancement of oxygen transport. The specific markers the module tests for include haematocrit, haemoglobin, red blood cell count, percentage of reticulocytes, reticulocytes count, mean corpuscular volume, mean corpuscular haemoglobin, mean red cell distribution width, and immature reticulocyte fraction.

The steroidal module collects information on markers for steroid doping and aims to identify endogenous anabolic androgenic steroids. The specific markers the module tests for include testosterone, epitestosterone, the testosterone/epitestosterone ratio, androsterone, and etiocholanolone.[6]

The World Anti-Doping Agency recently released the 2014 Prohibited Substances list and it will take effect on 1 January. In the new list, the agency modified the definitions of exogenous and endogenous steroids being tested for in the steroidal module of the biological passport.[7]

Cycling[edit]

Ricardo Serrano was one of the five first riders that UCI opened a biological passport case against, in 2009.[8]

Whereabouts rules[edit]

Under the new rules, registered riders have to give the Union Cycliste Internationale daily information about their location and provide a one-hour window for possible testing. They have to submit a form every quarter year saying where they will be every day of the next quarter and they must notify the UCI if they change their whereabouts on any day. This means the whereabouts information provided in the whereabouts filings is accurate and sufficient in detail to enable any relevant Anti-Doping Organization to locate him for testing on any given day in that period of time.[9] This is the most invasive testing programme in the history of any sport, but the UCI feels this invasion of privacy is justified as previously implemented anti-doping regimes have failed to detect every doping violation.

Cyclists sanctioned on the basis of their biological passport[edit]

The biological passport programme has allowed the UCI to sanction riders for committing an anti-doping rule violation. Riders have also been targeted with further doping controls based on their biological passport.

Name Country Event Date of infraction/
Start of disqualification
Sanction Sanction
announced
Ineligibility ending Reference(s)
António Amorim  Portugal Road racing 24 July 2010 2 years ineligibility 10 July 2013 14 April 2015 [10][11]
Igor Astarloa  Spain Road racing 2 years ineligibility [12]
Carlos Barredo  Spain Road racing 2 years ineligibility [13]
Leonardo Bertagnolli  Italy Road racing 2 years and 10 months ineligibility [14]
Pietro Caucchioli  Italy Road racing 2 years ineligibility [15]
Francesco De Bonis  Italy Road racing 2 years ineligibility [16]
Leif Hoste  Belgium Road racing 2 years ineligibility [17]
Rubén Lobato  Spain Road racing 2 years ineligibility 15 July 2012 [18]
Denis Menchov  Russia Road racing 2 years ineligibility [19]
Franco Pellizotti  Italy Road racing 2 years ineligibility [15]
Sérgio Ribeiro  Portugal Road racing 12 years ineligibility (second offence) [20]
Ricardo Serrano  Spain Road racing 2 years ineligibility [21]
Jonathan Tiernan-Locke  United Kingdom Road racing 2 years ineligibility [22]
Tadej Valjavec  Slovenia Road racing 2 years ineligibility [23]

During the first three years of UCI's bio passport program 26 riders were found positive for EPO. In 20 out of the 26 cases, it was the abnormal blood profile which raised suspicions leading to a targeted doping test.[24]

  • Antonio Colom tested positive for EPO in an out-of-competition control in April 2009, after having been targeted under the biological passport programme. He received a two-year sanction.[25]
  • Thomas Dekker tested positive for EPO in a retroactive test carried out on a urine sample taken in December 2007. Dekker's hematological profile led the UCI to review the EPO analyses for urine samples conducted since the introduction of the biological passport programme.[26]
  • David George tested positive for EPO in an out-of-competition control 29 August 2012, after having been targeted under the biological passport programme of the South African Institute for Drug-Free Sport (the South African national Anti-doping agency). He admitted to having used EPO and received a two-year sanction.[27][28]

Athletics[edit]

The International Association of Athletics Federations introduced their Athletes Biological Passport programme in 2009, and they announced the first sanction under the passport in May 2012.[29][30] The Portuguese marathon runner Hélder Ornelas became the first track and field athlete who got suspended for doping based on the biological passport.[29][30] He received a four year suspension in May 2012.[31]

Track and field athletes sanctioned on the basis of their biological passport[edit]

Name Country Event Date of infraction/
Start of disqualification
Sanction Sanction
announced
Ineligibility
starting
Ineligibility
ending
Reference(s)
Inga Abitova F  Russia Marathon 10 Oct. 2009 2 years ineligibility 7 Nov. 2012 11 Oct, 2012 10 Oct. 2014 [31][32]
Anna Alminova F  Russia 1500 m 16 Feb. 2009 2 years and 6 months ineligibility 30 July 2014 16 Dec. 2011 15 May 2014 [33]
Yelena Arzhakova F  Russia 800 m, 1500 m 12 July 2011 2 years ineligibility 30 April 2013 29 Jan. 2013 28 Jan. 2015 [31][34]
Ahmed Baday M  Morocco Long distance 26 March 2010 2 years ineligibility 6 March 2015 30 Dec. 2016 [35]
Sergey Bakulin M  Russia Race walking 25 Jan. 2011
–25 March 2011
16 June 2011
–16 Aug. 2011
11 April 2012
–11 June 2012
3 years and 2 months ineligibility 20 Jan. 2015 24 Dec. 2012 [36]
Alemitu Bekele F  Turkey 5000 m 17 Aug. 2009 2 years and 9 months ineligibility (Reduced from 4 years[37][38]) 16 Jan. 2013 3 March 2012 2 Jan. 2015 [31][39]
Petr Bogatyrev M  Russia Race walking 12 July 2011 2 years ineligibility 26 March 2014 16 Oct. 2013 15 Oct. 2015 [31][39]
Valeriy Borchin M  Russia Race walking 14 July 2009
–15 Sept. 2009
16 June 2011
–27 Sept. 2011
11 April 2012
–3 Sept. 2012
8 years ineligibility 20 Jan. 2015 15 Oct. 2012 [36]
Hamza Driouch M  Qatar 800 m, 1500 m. 2 Aug. 2012 2 years ineligibillity 24 Feb. 2015 31 Dec. 2014 30 Dec. 2016 [40][41]
Stanislav Emelyanov M  Russia Race walking 26 July 2010 2 years ineligibility 28 July 2014 15 Dec. 2012 14 Dec. 2014 [42][43]
Meryem Erdoğan F  Turkey Long-distance running 27 July 2010 2 years ineligibility 25 July 2012 14 Feb. 2014 [30][44]
Abderrahim Goumri M  Morocco Marathon 22 April 2009 4 years ineligibility 25 July 2012 14 March 2016[a] [30][44]
Yelizaveta Grechishnikova F  Russia 5000 m 18 Aug. 2009 2 years ineligibility 3 Dec. 2013 16 Oct. 2013 15 Oct. 2015 [31][45]
Halima Hachlaf F  Morocco 800 m 14 Oct. 2013 4 years ineligibility 24 April 2014 19 Dec. 2013 18 Dec. 2017 [31][46]
Hussain Al-Hamdah M  Saudi Arabia 5000 m 26 March 2009 2 years and 6 months ineligibility 22 Nov. 2013 15 Feb. 2013 14 Aug. 2015 [41][47]
Ekaterina Ishova (née Gorbunova) F  Russia 1500 m, 3000 m, 5000 m 12. July 2011 2 years ineligibility 3 Dec. 2013 23 Oct. 2013 22 Oct. 2015 [31][45]
Vladimir Kanaykin M  Russia Race walking 25 January 2011
–25 March 2011
16 June 2011
–27 Sept. 2011
Life ban 20 Jan. 2015 17 Dec. 2012 Life ban
(2nd ADRV)
[36]
Olga Kaniskina F  Russia Race walking 15 July 2009
–16 Sept. 2009
30 July 2011
–8 Nov. 2011
3 years and 2 months ineligibility 20 Jan. 2015 15 Oct. 2012 [36]
Natallia Kareiva F  Belarus 1500 m 28 July 2010 2 years ineligibility 29 Sept. 2014 22 Aug. 2014 21 Aug. 2016 [31][48][49]
Sergey Kirdyapkin M  Russia Race walking 20 July 2009
–20 Sept. 2009
29 June 2010
–29 Aug. 2010
17 Dec. 2011
–11 June 2012
3 years and 2 months ineligibility 20 Jan. 2015 15 Oct. 2012 [36]
Svetlana Klyuka F  Russia 800 m 15 Aug. 2009 2 years ineligibility 25 July 2012 9 Feb. 2014 [30][44]
Eirini Kokkinariou F  Greece Steeplechase 2 July 2009 4 years ineligibility 25 July 2012 27 Oct. 2011 26 Oct. 2015 [31][32]
Yekaterina Kostetskaya F  Russia 800 m, 1500 m 30 Aug. 2011 2 years ineligibility 28 July 2014 21 Jan. 2013 20 Jan. 2015 [42][43]
Mikhail Lemaev M  Russia Marathon 20 Aug. 2009 2 years ineligibility 26 Feb. 2013 30 Jan. 2013 29 Jan. 2015 [31][50]
Tatyana Mineeva F  Russia Race walking 12 Nov. 2011 2 years ineligibility 14 Dec. 2012 16 Nov. 2014 [31]
Marco Morgado M  Portugal Cross country running 29 Oct. 2011 6 years ineligibility 25 Feb. 2014 24 Feb. 2013 24 Feb. 2019 [31][51]
Sergey Morozov M  Russia Race walking 25 Feb. 2011 Life ban 18 Dec. 2012 Life ban
(2nd ARDV)
[31]
Maksym Cerrone Obrubanskyy M  Italy 1500 m, 3000 m. 5000 m 17 Feb. 2013 4 years ineligibility 25 Feb. 2014 30 May 2013 29 May 2017 [31][51]
Nina Okhotnikova F  Russia Race waling 21 June 2011
–17 Nov. 2011
2 years ineligibility 17 March 2015 22 Jan. 2015 21 Jan. 2017 [52][53]
Hélder Ornelas M  Portugal Marathon 8 March 2010 4 years ineligibility 2 May 2012 12 Jan. 2016 [30][31]
Tetiana Petlyuk F  Ukraine 800 m 18 Aug. 2009 2 years ineligibility 5 April 2013 19 Feb. 2015 [31]
José Rocha M  Portugal Long-distance running 11 Dec. 2010 2 years ineligibility 28 Feb. 2014 25 March 2013 24 March 2015 [31][54]
Yuliya Rusanova F  Russia 800 m 3 March 2011 2 years ineligibility 26 Feb. 2013 28 Jan. 2013 27 Jan. 2015 [31][50]
Andrey Ruzavin M  Russia Race walking 18 Dec. 2011
–18 Feb. 2012
12 Sept. 2013
–13 Nov 2013
2 years and 6 months ineligibility 17 March 2015 9 Oct. 2014 8 April 2017 [55][52][53]
Pınar Saka F  Turkey 400 m 18 June 2010 3 years ineligibility 28 Jan. 2014 3 June 2013 2 June 2016 [31][54]
Mohammed Shaween M  Saudi Arabia 1500 m 12 June 2011 3 years ineligibility 28 July 2014 13 Feb. 2013 12 Feb. 2016 [42][43]
Anzhelika Shevchenko F  Ukraine 1500 m 2 July 2011 2 years ineligibility 5 April 2013 17 Feb. 2015 [31]
Liliya Shobukhova F  Russia Marathon 9 Oct. 2009 2 years ineligibility 29 April 2014 24 Jan. 2015 [56]
Fernando Silva M  Portugal Cross country running 29 Oct. 2011 8 years ineligibility 26 Feb. 2014 24 Sept. 2013 23 Sept. 2021 [31][51]
Olesya Syreva F  Russia 1500 m, 3000 m 3 March 2011 2 years ineligibility 26 Feb. 2013 1 Feb. 2013 31 Jan. 2015 [31][50]
Wang Jiali F  China Marathon 29 May 2012 2 years ineligibility 25 Feb. 2014 26 Feb. 2013 25 Feb. 2015 [31][51]
Igor Yerokhin M  Russia Race walking 25 Feb. 2011 Life ban 24 Sept. 2013 Life ban
(2nd ARDV)
[31][57]
Lyudmyla Yosypenko F  Ukraine Heptathlon 25 Aug. 2011 4 years ineligibility 24 Sept. 2013 27 March 2013 26 March 2017 [31][57]
Nailiya Yulamanova F  Russia Marathon 2 years ineligibility 25 July 2012 9 Feb. 2014 [30][44]
Yuliya Zaripova F  Russia Steeplechase 20 June 2011
–20 Aug. 2011
3 July 2012
–3 Sept, 2012
2 years and 6 months ineligibility 30 January 2015 25 July 2013 [58]
Yevgeniya Zinurova F  Russia 800 m 6 March 2010 2 years ineligibility 25 July 2012 12 Sept. 2013 [30][44]

In March 2014 the Spanish athletics federation cleared Marta Dominguez in a bio passport case. El Pais reported that IAAF were going to take the case to CAS.[59] In February 2014 IAAF announced they would appeal Aslı Çakır Alptekins ABP related doping case to CAS after the Turkish federation had cleared her. IAAF also suspended her provisionally.[60] An IAAF spokesperson in January 2015 confirmed that Russian race walker Sergey Bakulin was provisionally suspended since December 2012 in an ABP related doping case.[61] IAAF otherwise doesn't publicly announce provisional suspensions. In February 2015 Turkish press reported that Ümmü Kiraz, Bahar Doğan, Semiha Mutlu and Meliz Redif were under investigation in bio passport cases.[62]

Football (soccer)[edit]

In 2014, the biological passport was introduced in the 2014 FIFA World Cup; blood and urine samples from all players before the competition and from two players per team and per match were analysed by the Swiss Laboratory for Doping Analyses.[63]

Notes[edit]

  1. ^ A. Goumri died in a car crash in January 2013

References[edit]

  1. ^ Swiss Laboratory for Doping Analyses. "Information on the athlete biological passport". 
  2. ^ Ashenden M. (March 2002). "A strategy to detect doping in sports". Haematologica (Haematologica) 87 (3): 225–32. PMID 11869930. 
  3. ^ "Q-A on the athlete passport". World Anti-Doping Agency. 
  4. ^ "Implementation of blood passport by UCI". UCI. 
  5. ^ Richard Moore (3 May 2008). "Blood tests cast doubt on 23 riders". The Guardian. 
  6. ^ http://www.wada-ama.org/Documents/Science_Medicine/Athlete_Biological_Passport/WADA-ABP-Operating-Guidelines_v4.0-EN.pdf
  7. ^ http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/2014/WADA-prohibited-list-2014-EN.pdf
  8. ^ Gregor Brown: UCI names first five biological passport violators, cyclingnews.com, 18 June 2009
  9. ^ http://www.uci.ch/includes/asp/getTarget.asp?type=FILE&id=NDc3MDk
  10. ^ Ciclista António Amorim suspenso devido à irregularidades no passaporte biológico, expresso.sapo.pt, 10 July 2013
  11. ^ Amorim bio-passport 10/07/2013 Violation #1101, dopeology.org
  12. ^ Barry Ryan. "Astarloa suspended and fined for UCI biological passport infraction". Cyclingnews.com. Retrieved 19 June 2014. 
  13. ^ UCI (10 July 2014). "UCI Doping Suspensions". UCI.ch. 
  14. ^ UCI (10 July 2014). "UCI Doping Suspensions". UCI.ch. 
  15. ^ a b "CAS upholds biological passport, slaps Pellizotti and Caucchioli with 2-year bans". VeloNews. 8 March 2011. 
  16. ^ Shane Stokes (22 June 2011). "CAS dismisses doping ban appeal by De Bonis over biological passport". Velonation.com. 
  17. ^ UCI (10 July 2014). "UCI Doping Suspensions". UCI.ch. 
  18. ^ UCI: Sanctions, Period of Ineligibily, Disqualification Sanctions, Période de Suspension, Disqualification
  19. ^ UCI (10 July 2014). "UCI Doping Suspensions". UCI.ch. 
  20. ^ Cycling News (4 August 2013). "Ribeiro handed 12 year ban by Portuguese federation". cyclingnews.com. 
  21. ^ "Biological Passport: Ricardo Serrano given two-year suspension by RFEC for EPO use". Velonation.com. 17 June 2010. 
  22. ^ http://www.bbc.co.uk/sport/0/cycling/28354686
  23. ^ "'Biological passport' pays off as Tadej Valjavec receives two-year ban". The Guardian. 22 April 2011. 
  24. ^ Dr. Dick Marty, Peter Nicholson, Dr. Ulrich Haas - Cycling Independent Reform Commission: Report to the President of the Union Cycliste Internationale, p.53
  25. ^ "Biological Passport: Antonio Colom sanctioned for two years, given large fine". Velonation.com. 27 May 2010. 
  26. ^ Susan Westemeyer (1 July 2009). "Dekker caught under biological passport programme". cyclingnews.com. 
  27. ^ David George gets 2-year ban, espn.com 5 December 2012
  28. ^ Former US Postal rider David George tests positive for EPO, velonation.com 6 November 2012
  29. ^ a b "Runner banned in doping case". ESPN. The Associated Press. 2 May 2012. Retrieved 16 July 2014. 
  30. ^ a b c d e f g h "Six new athletes sanctioned under the IAAF Athlete Biological Passport programme". iaaf.org. IAAF. 25 July 2012. Retrieved 16 July 2014. 
  31. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z "Athletes currently suspended from all competitions in athletics following an Anti-Doping Rule Violation as at: 26.06.14". iaaf.org. IAAF. 26 June 2014. Retrieved 16 July 2014. 
  32. ^ a b IAAF News Edition 138 - 18 December 2012, Athletes sanctioned for a doping offence since the last newsletter, According to information received by the IAAF as of 13 December 2012
  33. ^ "Doping sanctions - News 154 Positive cases in athletics Sanctioned according to information received by the IAAF as of 26 June 2014". iaaf.org. IAAF. 30 July 2014. Retrieved 1 August 2014. 
  34. ^ IAAF News Edition 143 - 28 May 2013 - Athletes Sanctioned for a Doping Offence since the last Newsletter, According to information received by the IAAF as of 22 May 2013
  35. ^ IAAF: Athletes currently suspended from all competitions in athletics following an Anti-Doping Rule Violation as at: 06.03.15, 6 March 2015
  36. ^ a b c d e RUSADA: Информация о дисквалификации: легкая атлетика, 20 January 2015
  37. ^ "Athletes currently suspended from all competitions in athletics following an Anti-Doping Rule Violation as at: 11.1.13". iaaf.org. IAAF. Retrieved 8 February 2015. 
  38. ^ Gregor Brown: Kreuziger faces difficult defense based on WADA and CAS history, Velonews, 4 March 2015
  39. ^ a b Positive cases in athletics Sanctioned according to information received by the IAAF as of March 2014
  40. ^ Associated Press: Qatari middle-distance runner given two-year doping ban, Washington Post, 24 February 2015
  41. ^ a b IAAF: Positive cases in athletics Sanctioned according to information received by the IAAF as of 20 February 2015
  42. ^ a b c "List of athletes currently serving a period of ineligibility as a result of an Anti-Doping Rule Violation under IAAF Rules as at: 28.07.14". IAAF. 28 July 2014. Retrieved 31 July 2014. 
  43. ^ a b c Positive cases in athletics SANCTIONED ACCORDING TO INFORMATION RECEIVED BY THE IAAF AS OF JULY – AUGUST 2014
  44. ^ a b c d e "Athletes currently suspended from all competitions in athletics following an Anti-Doping Rule Violation as at: 11.1.13". IAAF. 11 January 2013. 
  45. ^ a b IAAF Newsletter Edition 148 - 3 December 2013
  46. ^ Positive cases in athletics Sanctioned according to information received by the IAAF as of 28 April 2014
  47. ^ 2 Saudi athletes banned for doping offenses, Yahoo Sports, 22 November 2013
  48. ^ Ändrade resultatlistor, friidrott.se 2 October 2014
  49. ^ IAAF: Doping sanctins News 156
  50. ^ a b c IAAF News Edition 140 - 26 February 2013
  51. ^ a b c d IAAF News Edition 150 | 25 February 2014
  52. ^ a b Associated Press: 2 more Russian race walker banned for doping violations, espn.com, 17 March 2015
  53. ^ a b Russian Athletics Federation: Дисквалификация, 17 March 2015
  54. ^ a b IAAF News Edition 149 | 28 January 2014
  55. ^ Dmitriy Rogovitskiy: Russian walker Ruzavin banned for doping, ca.sports.yahoo.com, 17 March 2015
  56. ^ Peter Gambaccini: Liliya Shobukhova Gets Two-Year Doping Ban, Runners World & Running Times, 29 April 2014
  57. ^ a b IAAF News Edition 146 - 24 September 2013
  58. ^ RUSADA: Russian athletes (athletics) recognized ineligible, 30 January 2015
  59. ^ Spanish athletics federation acquits Marta Domínguez in doping probe, El Pais, 20 March 2014
  60. ^ "Asli Cakir Alptekin again banned". Associated Press. 13 February 2014. 
  61. ^ Associated Press: Another Russian race-walker under scrutiny, New Zealand Herald, 17 January 2015
  62. ^ Bir doping vakası daha Uluslararası Atletizm Federasyonu (IAAF) ve Uluslararası Anti Doping Ajansı (WADA), Türkiye Atletizm Federasyonu'na 4 atletin biyolojik pasaportunda doping tespit ettiğini bildirdi. Alınan bilgilere göre bu sayı artabilir..., Hürriyet, 28 February 2015
  63. ^ (French) Anti-dopage. Dvorak : "Le profil biologique, une approche complètement nouvelle", fifa.com (page visited on 11 June 2014).

External links[edit]