Bipolar disorder in children

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Bipolar disorder (BD) in children, or pediatric bipolar disorder (PBD), formerly known as "manic depression", is characterized by extreme changes in mood that range from depressive "lows" to manic "highs" (typified by feelings of excessive happiness or rage). It is important to note that these moods exceed normal responses to life events, represent a change from the individual's normal functioning, and cause problems in daily activities - for instance, in getting along with family, friends and teachers, or in completing schoolwork.

Identifying BD in youth is challenging because, while adults with BD often have distinct periods of depression and mania that last for weeks, months, or longer, youth diagnosed with BD frequently have depressive and manic symptoms that occur daily, and sometimes simultaneously. Comorbid disorders are common, which makes determining what symptoms are signs of BD and which are due to other disorders (e.g., depression, ADHD, disruptive behavior problems) critical.

History[edit]

Emil Kraepelin

Emil Kraepelin in the 1920s noted that mania episodes were rare before puberty.[1] In general BD in children was not recognized in the first half of the 20th century with first reviews of cases being published in the 1960s.[1][2] True recognition came twenty years after, with epidemiological studies showing that in approximately 20% of adults with BD already had symptoms in childhood or adolescence.[1] Nevertheless onset before age 10 was thought to be rare, below 0.5% of the cases.[1] During the second half of the century misdiagnosis with schizophrenia was not rare in the non-adult population due to common co-occurrence of psychosis and mania, this issue diminishing with an increased following of the DSM criteria in the last part of the 20th century.[1]

Signs and symptoms[edit]

Severe manic and depressive symptoms are associated with early age of diagnosis, meaning children often display more acute symptoms than adults.[3] In children, mania often presents with psychotic symptoms and mixed manic depressive episodes.[1] Such a presentation of mania often differs from classic descriptions of mania in adults, yet children who are diagnosed with bipolar disorder show the same brain abnormalities as adults, further complicating diagnosis.[1] Children with PBD display anger, dysphoria, irritability, belligerence, and mixed-manic depressive symptoms more commonly and for more erratic time periods than adults.[1][4] Bipolar disorder is episodic, which means the symptoms do not always appear and may come and go at random times. The need for both elation and grandiosity is recommended and supported by many studies. "Findings from the Course and Outcome of Bipolar Illness among Youth (COBY) study, for example, suggest that, in about 80% of the cases, both elation and irritability are present during the most severe symptomatic episodes among youth with BD…"[5] This requirement is not in the current issue of the DSM, but may be in the future.[citation needed]

Depressive symptoms of BD often include sadness, irritability, an inability to enjoy one's usual activities, changes in appetite or weight, and/or sleeping more than normal or having difficulty falling/staying asleep even when tired. Manic symptoms of BD may include: inflated or unrealistic self-esteem; less need for sleep; talking more/faster than normal; changing the topic of conversation so quickly/often that it interferes with communication; experiencing "racing" thoughts; increased distractability; difficulty sitting still; an unusual drive to engage in activities or pursue goals; and engaging in risky or dangerous behaviors.[citation needed]

Pediatric bipolar disorder causes a significant impairment in the ability of children to function normally, especially in academics and psychosocial areas, and it is a chronic disorder that persists throughout the lifetime.[4][6] Children with PBD experience chronic periods of mania, characterized by elevated and irritable moods, or depression. The DSM-IV-TR states that the requirements for mania include inflated self-esteem, decreased need for sleep, and being more talkative than usual.[5]

It is important to be able to tell the difference between a decreased need for sleep and insomnia which is the difficulty of falling or staying asleep. The American Academy of Childhood and Adolescent Psychology (AACAP) states that the same, unalthered DSM-IV-TR criteria should be used with children, adolescents, and adults. PBD patients are ten times more likely to commit suicide than healthy children.[3][7]

Diagnosis[edit]

The diagnosis of childhood BD is controversial,[8] although it is not under discussion that BD typical symptoms are dysfunctional and have negative consequences for minors suffering them.[1] Main discussion is centered on whether what is called BD in children refers to the same disorder than when diagnosing adults,[1] and the related question on whether adults' criteria for diagnosis are useful and accurate when applied to children.[8] More specifically main discussion over diagnosis in children circles around mania symptomatology and its differences between children and adults.[8] For the diagnosis of mania the American Psychiatric Association's Diagnostic and Statistical Manual (DSM-IV-TR) requires a "distinct period of abnormally and persistently elevated, expansive or irritable mood" during at least four days, and a number of extra behavioral and cognitive symptoms such as grandiosity, reduced sleep need and risk seeking behaviors.[8]

Experts recommend to follow the same DSM criteria than for adults while taking into account the age of the individual and the normal behavior of those of his age.[8] Others believe that these criteria do not separate correctly children with BD from other problems such as ADHD, and emphasize fast mood cycles.[8] Still others argue that what accurately differentiates children with BD is the distinct irritability with which it courses.[8] The practice parameters of the American Academy of Child and Adolescent Psychiatry encourage the first strategy.[1][8] A way to determine the differences between PBD and other childhood mood disorders such as ADHD and conduct disorder, is the prevalence of irritability in addition to extreme elation, other manic symptoms, and if it is episodic.

Family history, and the use of questionnaires, checklists, and diagnostic interviews have been helpful in diagnosing children with bipolar disorder.[5] Differences in diagnostic practices [use of "OR" (considering either child or parent response to questions) or "AND" (combining parent and child's responses) criteria] influences diagnosis of PBD and ADHD. It is notable that some studies consider parents' answers alone; some mix children and parent responses. Study setting, diagnostic sample, and conceptualization differences (episodic vs non-episodic; irritability as diagnostic criterion; modified diagnostic criteria) also influence diagnosis.[9]

The DSM-V has introduced a new type of mood disorder called Disruptive Mood Dysregulation Disorder (DMDD) that could impact children who have either already been diagnosed with or are in the process of being diagnosed with childhood bipolar disorder.[10] DMDD was originally called Temper (or Tantrum) Dysregulation Disorder with Dysphoria (TDD), but the name was changed as it was felt that it might carry too much negativity in relation to "typical" temper tantrums.[10] The DSM-5’s new diagnosis of DMDD was created to address the "over-diagnosis" of bipolar disorder in children who experience explosive rages.[10] To be diagnosed with DMDD a child must have at least three temper outbursts every week for a year, in at least two different settings.[11]

Increase[edit]

Number of American children and adolescents diagnosed of BD in community hospitals increased 4-fold reaching rates of up to 40% in 10 years around the beginning of the current century, while in outpatient clinics it doubled reaching the 6%.[8] Outpatient office visits for children and adolescents with bipolar disorder in the United States increased from 20,000 in 1994–95 to 800,000 in 2002–03.[12] The data suggest that doctors had been more aggressively applying the diagnosis to children, rather than that the incidence of the disorder has increased.[13]

The reasons for this increase in diagnosis are unclear. On the one hand, the recent consensus from the scientific community (see above) will have educated clinicians about the nature of the disorder and the methods for diagnosis and treatment in children. That, in turn, should increase the rate of diagnosis. On the other hand, assumptions regarding behavior, particularly in regard to the differential diagnosis of bipolar disorder, ADHD, and conduct disorder in children and adolescents, may also play a role. In addition, some argue that the rise in diagnosis of pediatric bipolar disorder is the result of the influence of the pharmaceutical industry on psychiatry, especially with regard to big pharma's recent push to expand the market of atypical antipsychotics to children and the elderly.[14] Another possible reason for the recent increase in diagnoses is a shift in the diagnostic pendulum.[13] In previous years, there has been an issue with bipolar disorder being under-diagnosed, but now, as more information get published and more people are gaining a better understanding of what it means to have bipolar disorder, more people are being given this diagnosis.[citation needed]

National differences[edit]

Another issue is that the consensus regarding the diagnosis in the pediatric age group may only apply to the US. The British National Institute on Health and Clinical Excellence (NICE) guidelines on bipolar disorder in 2006[15] specifically described the broadened criteria used in the US to diagnose bipolar disorder in children as suitable "only for research" and "were not convinced that evidence currently exists to support the everyday clinical use of (pediatric bipolar phenotype) diagnoses" which increase the "risk that medicines may be used to inappropriately treat a bipolar diathesis that does not exist."(p526). A 2002 German survey [16] of 251 child and adolescent psychiatrists (average 15 years clinical experience) found only 8% had ever diagnosed a pre-pubertal case of bipolar disorder in their careers. A similar survey of 199 child & adolescent psychiatrists (av 15 years clinical experience) in Australia and New Zealand [17] also found much lower rates of diagnosis than in the US and a consensus that bipolar disorder was overdiagnosed in children and youth in the US. Concerns about overdiagnosis in the US have also been expressed by American child & adolescent psychiatrists [18][19][20][21] and a series of essays in the book "Bipolar children: Cutting-edge controversy, insights and research" [22] highlight several controversies and suggest the science still lacks consensus with regard to bipolar disorder diagnosis in the pediatric age group.

Epidemiology[edit]

Prevalence of children who meet DSM criteria for BD is around 2%,[23] but it can be argued that DSM criteria are interpreted differently by different researchers.[24] For example ultradian cycling of mood is highly controversial as having validity for episodes of mania or hypomania as a more traditional interpretation requires sustained manic/hypomanic mood states over several days to weeks or months.

Studies in clinics using these criteria show that up to 20% of youth referred to psychiatric clinics have bipolar disorder.[25][26]

Assessment[edit]

Diagnostic Changes[edit]

There have been diagnostic changes for pediatric bipolar disorder from DSM-IV to DSM-5, and they can be found here and here.

Demographic Information[edit]

This section describes the demographic setting of the population(s) sampled, base rates of diagnosis, country/region sampled and the diagnostic method that was used.

Base Rates of PBD in different clinical settings[edit]

Setting Reference Base Rate Demography Diagnostic Method
National Comorbidity Survey-Adolescent

(NCS-A)

Kessler et al., 2012[27] 3.0% All of U.S.A. Composite International Diagnostic Interview (CIDI) 3.0
Community Epidemiologic Samples Van Meter, Moreira, & Youngstrom, 2011[23] 1.2% U.S.A., Netherlands, U.K., Spain, Mexico, Ireland, New Zealand Structured and semi-structured diagnostic interviews
Inpatient Services/Diagnoses Holtmann et al., 2008[28] 0.3% All of Germany International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10)
Community Sample Olino et al., 2012[29] 2.9% Oregon LIFE, SCID, DSM-IV
Inpatient Service Carlson & Youngstrom, 2003[30] 30% manic symptoms, <2% strict BP I New York City Metro Region DICA; KSADS

Brief Screening Tools[edit]

The following are brief screening tools that typically takes less than 5 minutes to administer to accurately diagnose pediatric bipolar disorder:

7 Up 7 Down Inventory (7U7D)[edit]

The 7 Up 7 Down Inventory[31] is a recently developed and validated questionnaire with 14 items of manic and depressive tendencies carved from the General Behavior Inventory, a well-validated but cumbersome interview. For both mania and depression factors, 7 items produced a psychometrically adequate measure applicable across both aggregate samples. Internal reliability of the Mania scale was .81 (youth) and .83 (adult) and for Depression was .93 (youth) and .95 (adult).[31]

PGBI-10M[edit]

The PGBI-10M[32] is a brief (10 item) instrument derived from the Parent General Behavior Inventory (P-GBI),[33] a 73-item mood inventory, to assess mania in a large sample of outpatients presenting with a variety of different DSM-IV diagnoses, including frequent comorbid conditions.[32] The 10-item GBI derived from the 73-item P-GBI had good reliability (alpha = .92), correlated (r = 0.95) with the 28-item scale, and showed significantly better discrimination of bipolar disorders (area under the receiver operating characteristic [AUROC] curve of 0.856 vs. 0.832 for the 28-item scale, p < .005). The 10-item scale also did well discriminating bipolar from unipolar (AUROC = 0.86) and bipolar from attention-deficit/hyperactivity disorder (AUROC = 0.82) cases.[32]

"Gold" Standard Diagnostic Interviews[edit]

The following diagnostic interviews are recommended as best currently available "gold" standards for accurate diagnosis of pediatric bipolar disorder:[34]

Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime (KSADS-PL)[edit]

The Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime (KSADS-PL) is a semi-structured diagnostic interview that assesses current and past Diagnostic and Statistical Manual of Mental Disorders – Fourth Edition (DSM-IV-TR) Axis I psychopathology in youth.[35] The KSADS-PL diagnostic interviews have good inter-rater (.93 to 1.00) and retest reliability (.77) for mood disorders [36]

Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS)[edit]

The Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia[37](WASH-U-KSADS) was expanded from the 1986 version of the KSADS, which was modified and expanded to include onset and offset of each symptom for both current and lifetime episodes, expanded prepubertal mania and rapid cycling sections, and categories for attention deficit hyperactivity disorder and other DSM-IV diagnoses. To optimize diagnostic research, skip-outs were minimized.

The kappa values of comparisons between research nurse and off-site blind best-estimate ratings of mania and rapid cycling sections were excellent (0.74-1.00). High 6-month stability for mania diagnoses (85.7%) and for individual mania items and validity against parental and teacher reports were previously reported.[37]

Parent-General Behavior Inventory (P-GBI)[edit]

The Parent-General Behavior Inventory (P-GBI) [33] is a parent report measure of depressive and hypomanic/biphasic symptoms adapted from the General Behavior Inventory (GBI).

Overall classification accuracy rates exceed 80%, and receiver operating characteristic analyses showed good diagnostic efficiency for the scales, with areas under the curve greater than .80. Results indicate that clinicians can use the parent-completed GBI to derive clinically meaningful information about mood disorders in youths.[33]

Interpreting PBD screening measure scores[edit]

Baynesian probability theory can be used in order to accurately predict the diagnosis of pediatric bipolar disorder, given base diagnosis rate in the region and diagnostic likelihood ratios.

Area Under Curve (AUC)[edit]

The area under the curve (AUC, or AUROC) is equal to the probability that a classifier will rank a randomly chosen positive diagnosis of PBD higher than a randomly chosen negative diagnosis of PBD.

Likelihood Ratios[edit]

Likelihood ratios (also known as likelihood ratios in diagnostic testing) are the proportion of cases with the diagnosis scoring in a given range divided by the proportion of the cases without the diagnosis scoring in the same range.[38][39] The table below shows area under the curve (AUCs) and likelihood ratios for potential screening measures for pediatric bipolar disorder. It should be noted that all studies used some version of a K-SADS interview by a trained rater, combined with review by a clinician to establish consensus.

Likelihood Ratio Comments
Larger than 10, smaller than 0.10 Frequently clinically decisive
Ranging from 5 to 10, 0.20 Helpful in clinical diagnosis
Between 2.0 and 0.5 Rarely result in clinically meaningful changes of formulation
Around 1.0 Test result did not change clinical impressions at all

"LR+" refers to the change in likelihood ratio associated with a positive test score, and "LR-" is the likelihood ratio for a low score. Likelihood ratios of 1 indicate that the test result did not change impressions at all.[38] On the other hand, likelihood ratios larger than 10 or smaller than 0.10 are frequently clinically decisive, 5 or 0.20 are helpful, and between 2.0 and .5 are small enough that they rarely result in clinically meaningful changes of formulation.[40]

Area under Curve (AUCs) and Likelihood Ratios for PBD Potential Screening Measures[edit]

Screening Measure Cut-off scores (LR+/LR-) Likelihood Ratios (LR+/LR-) Population Area under curve (AUC) and Sample Size Citation
CBCL Externalizing T-Score Above 81, below 54 4.3/0.04 Bipolar spectrum vs. all other diagnoses 0.78

(N=324)

Youngstrom, Findling, Calabrese et al., 2004[41]
CBCL Attention, Aggressive, Anxious/Depressed T-Score (Parent) Above 60, less than 60 4.67/0.5 Bipolar spectrum vs. all other diagnoses 0.81

(N=101)

Meyer et al., 2009[41]
TRF Externalizing T-Score Above 77, less than 46 3.8/0.25 Bipolar spectrum vs. all other diagnoses 0.70

(N=324)

Youngstrom, Findling, Calabrese et al., 2004[41]
Youth Self Report (YSR) Externalizing T-Score Above 77, less than 49 3.0/0.31 Bipolar spectrum vs. all other diagnoses 0.71

(N=324)

Youngstrom, Findling, Calabrese et al., 2004[41]
Parent General Behavior Inventory

(P-GBI) (Hypomanic/Biphasic Section)

Above 49, below 9 9.2/0.06 Bipolar spectrum vs. all other diagnoses 0.84

(N=324)

Youngstrom, Findling, Calabrese et al., 2004[41]
Parent Mood Disorder Questionnaire

(P-MDQ)

Above 6, below 9 4.64/0.17 Bipolar spectrum vs. all other diagnoses 0.84

(N=819)

Wagner et al., 2006[42]
Conners' Abbreviated Parent Questionnaire[43] Above 8, less than 3 5.21/0.31 Bipolar spectrum vs. ADHD 0.85

(N=150)

Henry et al., 2008[44]
Child Mania Rating Scale (Brief)

(Brief CMRS-P)

Above 10/not reported 10.5/0.17 Bipolar spectrum vs. ADHD 0.85

(N=150)

Henry et al., 2008[44]
Child Mania Rating Scale (Full)

(Full CMRS-P)

Above 20, not reported 13.7/0.19 Bipolar spectrum vs. ADHD 0.91

(N=150)

Henry et al., 2008[44]
Child Bipolar Questionnaire

(CBQ-P)

not reported 25.3/0.25 Bipolar spectrum vs. all other diagnoses 0.74

(N=497)

Papolos et al. (2010)[45]

Clinically Significant Change Benchmarks with Common Instruments and Mood Rating Scales[edit]

Listed below are clinically significant change benchmarks of common screening instruments used for pediatric bipolar disorder.

Measure Subscale Cut-off scores Critical Change
(unstandardized scores)
Benchmarks Based on Published Norms
A B C 95% 90% SEdifference
Beck Depression Inventory[46] BDI Mixed Depression 4 22 15 9 8 4.8
CBCL T-scores
(2001 Norms)
Total 49 70 58 5 4 2.4
Externalizing 49 70 58 7 6 3.4
Internalizing n/a 70 56 9 7 4.5
Attention Problems n/a 66 58 8 7 4.2
TRF T-scores
(2001 Norms)
Total n/a 70 57 5 4 2.3
Externalizing n/a 70 56 6 5 3.0
Internalizing n/a 70 55 9 7 4.4
Attention Problems n/a 66 57 5 4 4.8
YSR T-scores
(2001 Norms)
Total n/a 70 54 7 6 3.3
Externalizing n/a 70 54 9 8 4.6
Internalizing n/a 70 54 9 8 4.8
Benchmarks Based on Bipolar Spectrum Samples
Gracious et al., 2002[47]
Young Mania Rating Scale - Parent
(Full)
n/a 5.2 22.1 14.4 4.3 3.6 2
Young Mania Rating Scale - Parent
(Brief)
n/a 6.8 27.4 17.5 5 4.2 2.5
Carlson & Youngstrom, 2003[30]
Teacher-Completed Teacher Self-Control Rating Scale n/a 32.4 110.6 72.6 11.6 9.7 5.75
Inpatient Global Rating Scales n/a 1.9 90.7 50.8 15.7 13.2 7.21
Cooperberg, 2002
Young Mania Rating Scale (Clinician Rated) n/a 6 2 2 12 10 6.2
Child Depression Rating-Revised (CDRS-R) n/a n/a 40 29 8 7 4
Parent GBI Hypomanic/Biphasic 7 19 15 8 7 4.2
Depression n/a 18 13 7 6 3.6
Adolescent GBI Hypomanic/Biphasic n/a 32 19 8 7 4.4
Depression n/a 47 27 10 9 5.2

Treatment[edit]

Medications can produce important side effects so interventions have been recommended to be closely monitored and families of patients be informed of the different possible problems that can arise.[1] Atypical antipsychotics may produce weight gains as well as other metabolic problems, including diabetes mellitus type 2 and hyperlipidemia.[1] Extrapyramidal secondary effects may appear with these medications. These include tardive dyskinesia, a difficult-to-treat movement disorder (dyskinesia) that can appear after long-term use of anti-psychotics.[1] Liver and kidney damage are a possibility with mood stabilizers.[1] The drugs most commonly used are mood stabilizers and atypical antipsychotics.

Psychological treatment usually includes some combination of education on the disease, group therapy and cognitive behavioral therapy.[8] Children with BD and their families are informed, in ways accordingly to their age and family role, about the different aspects of BD and its management including causes, signs and symptoms and treatments.[8] Group therapy aims to improve social skills and manage group conflicts, with role-playing as a critical tool.[8] Finally cognitive-behavioral training is directed towards the participants having a better understanding and control over their emotions and behaviors.[8]

Family therapy has strong support for treatment of pediatric bipolar disorder. Family Therapy is a branch of psychotherapy that works with families. It tends to view change in terms of the systems of interactions between family members. Families are seen as an interconnected force where the actions of the family members affect the health or dysfunction of each individual and the family as a whole. Family therapists focus on relationship patterns and are generally more interested in what goes on between family members rather than within one or more individuals. One family member may have a problem and the family relationships may be contributing to or maintaining that problem. For example, when a child has a behavior problem, family therapists may see the child as a 'scapegoat' and view the problem as actually residing within the family system. Family therapists avoid blaming any family member for the problem, and instead help the family interact in different ways that may solve the problem. There are both general, historical models of Family therapy (i.e., Structural, Strategic, Bowenian) and more specific, evidence-based approaches that are based on the earlier models. Strong research evidence suggests that both general and specific family therapy approaches are effective with a wide variety of clinical problems, including the treatment of bipolar spectrum disorders.[48]

Cognitive behavioral therapy (CBT) is also effective in treating bipolar disorder in young people. CBT is the term used for a group of psychological treatments that are based on scientific evidence. These treatments have been proven to be effective in treating many psychological disorders among children and adolescents, as well as adults.[49]

When all treatment options are ineffective clozapine and electroconvulsive therapy have been proposed as last choice possibilities.[8]

Prognosis[edit]

Chronic medication is often needed, with relapses of individuals reaching rates over 90% in those not following medication indications and almost to 40% in those complying with medication regimens in some studies.[8] Compared to adults, a juvenile onset has in general a similar or worse course, although age of onset predicts the duration of the episodes more than the prognosis.[1] A risk factor for a worse outcome is the existence of additional (comorbid) pathologies.[1] Some children, such as Rebecca Riley have died as a direct result of psychiatric labels and drugging to control their behavior but the practice continues.

Controversy[edit]

The diagnosis of bipolar disorder in children is a controversial topic. While some believe the DSM-IV-TR criteria should be followed others have proposed other behavioral markers specific for children BD. The DSM-5 may include a new type of mood and conduct disorder, Disruptive Mood Dysregulation Disorder, as a replacement for most pediatric bipolar diagnoses.[50] Some prominent psychiatrists, such as Stuart Kaplan [51] and Allen Frances,[52] advocate applying less severe and better-researched diagnoses such as ADHD and Oppositional Defiant Disorder instead of pediatric bipolar disorder. Another origin for controversy is the rise in the number of diagnoses in the last years, almost exclusively in the US, with several possible causes for this increase. It has been argued that several factors including biomedical reductionism, neglect of trauma and attachment factors, the symptom checklist but decontextualised model of psychiatric nosology embodied in DSM, influence of the pharmaceutical industry and "diagnostic upcoding" particularly in the US health system have contributed to the epidemic of pediatric BD.[53]

Research directions[edit]

Research directions for BD in children include optimizing treatments for this population through well designed clinical trials, increasing the knowledge of the genetic and neurobiological basis of the pediatric disorder, finding out why so many pediatric cases are among boys whereas many adult cases are in women, and improving diagnostic criteria.[8] Regarding the latter, the mental health professionals charged with forming the new Diagnostic and Statistical Manual for Mental Disorders (the DSM-V) have proposed a new diagnosis, disruptive mood dysregulation disorder, which (though it is still thought[by whom?] to be some kind of biologically based mental illness requiring drug and psychotherapeutic treatment) is considered to cover some presentations involving behavioral outbursts in different settings and locations that is thought of as simple childhood-onset bipolar disorder occurring before puberty.[54][55] To be ethical, researchers must obtain the full and informed consent of participating human subjects including the children when experimenting on them with psychotropic (mind-altering) drugs.[citation needed]

A 2006 study conducted by the National Institutes of Health examined neural mechanisms involved in how children with bipolar disorder process faces of other individuals (average age 14.21 ± 3.11 years old) in order to study amygdala dysfunction.[56] The use of Functional magnetic resonance imaging looked at neural activation in relation to emotional aspects of faces (i.e. hostility, fear) vs. nonemotional aspects (nose width). Compared with controls, patients showed greater hostility when viewing neutral faces and reported more fear when viewing them. Also, compared with controls, patients had greater activation in the left amygdala, accumbens, putamen, and ventral prefrontal cortex when saying how hostile they viewed faces, and higher levels of activation in the left amygdala and bilateral accumbens when they rated the fearfulness of faces. This study emphasized the differences in abnormal emotion-attention in children with Bipolar disorder that may interpret facial expressions of those around them.

See also[edit]

References[edit]

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Further reading[edit]

Handbooks for researchers and clinicians[edit]

Bipolar Disorder in Childhood ad Early Adolescence. Gellar, B., & BelBello, M. (ed)

Resources for parents[edit]