The station opened as part of the former Line 2 South on 24 April 1906, when it was extended from Passy to Place d'Italie. On 14 October 1907 Line 2 South was incorporated into Line 5. It was incorporated into line 6 on 12 October 1942. The station was called Quai de Grenelle until 1949, when it was renamed to commemorate the Battle of Bir Hakeim. A commemorative panel is situated at the entrance of the platform for trains traveling towards Nation. The station was the location of the Barrière de la Cunette, a gate built for the collection of taxation as part of the Wall of the Farmers-General; the gate was built between 1784 and 1788 and demolished in the nineteenth century.