Bis-tris methane

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Bis-tris methane
Skeletal formula of bis-tris methane
CAS number 6976-37-0 N
PubChem 81462
ChemSpider 73505 YesY
EC number 230-237-7
MeSH Bistris
ChEBI CHEBI:41250 YesY
RTECS number TY2900000
Beilstein Reference 2205275
Gmelin Reference 4519
Jmol-3D images Image 1
Molecular formula C8H19NO5
Molar mass 209.24 g mol−1
Appearance White crystals
Odor Odourless
Melting point 102 to 103 °C (216 to 217 °F; 375 to 376 K)
Solubility in water 209.2 g L−1 (at 20 °C)
Acidity (pKa) 6.46
Basicity (pKb) 7.54
λmax 280 nm
Absorbance 0.15
GHS pictograms The exclamation-mark pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
GHS signal word WARNING
GHS hazard statements H315, H319, H335
GHS precautionary statements P261, P305+351+338
EU classification Irritant Xi
R-phrases R36/37/38
S-phrases S26, S36
NFPA 704
Flammability code 0: Will not burn. E.g., water Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Related compounds
Related alkanols
Related compounds Diethylhydroxylamine
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Bis-tris is an abbreviation of the trivial name (Bis(2-hydroxyethyl)-amino-tris(hydroxymethyl)-methane) for 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol. It is generally used as a buffering agent in biochemistry. Bis-tris is an organic tertiary amine with labile protons having a pKa of 6.46 at 25°C. It is an effective buffer between the pH 5.8 and 7.3.

See also[edit]


  1. ^ "Bistris - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 23 June 2005. Identification. Retrieved 9 April 2012.