Bleiblerville was named for Robert Bleibler, a Swiss immigrant, who ran the general store, post office, and saloon. Bleibler opened the general store in the area in the late 1880s. The community grew rapidly with the influx of many German immigrants in the late nineteenth century, and its post office was established in 1891. The community expanded in the 1960s with the increase of oil drilling in the community, but has since declined.
Bleiblerville is situated on FM 2502 a distance of 3.4 miles (5.5 km) northwest of its intersection with State Highway 159 at Nelsonville and 12.1 miles (19.5 km) northwest of Bellville. From Bleiblerville northwest to the intersection of FM 2502 and Farm to Market Road 109 near Welcome is 2.9 miles (4.7 km). From the center of Bleiblerville, Industry Road snakes its way to the southwest a distance of 3.8 miles (6.1 km) to Industry. Bleiblerville Road leaves the community heading northeast and connects with New Wehdem Road to cover the 8.9 miles (14.3 km) to an intersection with State Highway 36 south of Brenham. Bleiblerville addresses extend northwest along FM 2502 as far as the FM 109 intersection, but only a short distance to the southeast. The Bleiblerville postal zone extends as far as Industry Road and Begonia Lane to the southwest and to Bleiblerville and West Uekert Roads to the northeast.