The street, which is parallel to Hamra Street, runs east-west, connecting with Rue Clémenceau on the east and ending at Avenue General Charles de Gaulle that runs along the coast of the Mediterranean. The street is named after Dr. Daniel Bliss, an American missionary who founded the American University of Beirut. Prior to the mid-1960s, the tram passed along Bliss Street and stopped in front of AUB's Main Gate. 
On the other side it is lined with many historical and commercial buildings that house cafes, restaurants, pubs as well as bookstores. Bliss Street has one of the largest concentration of restaurants in Beirut, such as Uncle Sam's and Bliss House, that cater to the university students who hang out on the street.
- Never by Blood By Noel Carroll
- "They were on Shari Bliss, or Bliss Street, and closing in on the American University of Beirut, their first destination of the day."
- Carter, Dunston, and Thomas. Syria and Lebanon, page 226
- Anderson, Gerald H. Biographical Dictionary of Christian Missions, page 69
- Shehadeh, Raja. Strangers in the House: Coming of Age in Occupied Palestine, page 79
- Carter, Dunston, and Thomas. Syria and Lebanon, page 285
- Mannheim, Ivan. Syria & Lebanon Handbook: the Travel Guide, page 428