The song features in the film Grosse Pointe Blank. Since the original master tapes were not available for use in the film the band recorded a new version of the song, entitled "Blister 2000". A new music video was created for the original version of the song, coinciding with the release of the film. It features Gordon Gano as a deranged assassin trying to kill Socks the cat in puppet form, as well as clips from the film.
In August 2007, Gordon Gano was the subject of a lawsuit brought by bassist Brian Ritchie. The lawsuit stems partly from Gano's authorization of the use of "Blister" in a Wendy's commercial. In 2008, the song was featured on a Foster's Lager "Stealing Shadows" advert.