Blood–air barrier

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Alveolar–capillary barrier
Alveoli.svg
Gaseous exchange in the lung
MeSH Blood-Air+Barrier
Code TH H3.05.02.0.00040

The blood–air barrier (alveolar–capillary barrier or membrane) exists in the gas exchanging region of the lungs. It exists to prevent air bubbles from forming in the blood, and from blood entering the alveoli. It is formed by the type 1 pneumocytes of the alveolar wall, the endothelial cells of the capillaries and the basement membrane between the two cells. The barrier is permeable to molecular oxygen, carbon dioxide, carbon monoxide and many other gases.[1]

This blood gas barrier is extremely thin (approximately 2μm) (600–800 nm; in some places merely 200 nm) to allow sufficient oxygen diffusion, yet it is extremely strong. This strength comes from the type IV collagen in between the endothelial and epithelial cells. Damage can occur to this barrier at a pressure difference of around 40 millimetres of mercury (0.053 bar).

Failure of the barrier is often seen in racehorses and other domesticated horses due to exercise induced blood pressure rising above normal.[citation needed]

Failure of the barrier may occur in a pulmonary barotrauma. This can be a result of several possible causes, including blast injury, and breathing gas entrapment or retention in the lung during depressurization, which can occur during ascent from underwater diving or loss of pressure from a pressurized vehicle, habitat or pressure suit.

A possible consequence of rupture of the blood–air barrier is arterial gas embolism

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References[edit]

  1. ^ Sheenan Kindlen (2003). Physiology for Health Care and Nursing. Elsevier Health Sciences. p. 130. ISBN 0-443-07116-0. 

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