Ferguson attended Troy High School in Troy, Ohio.Ferguson's first year of eligibility at Ohio State was 1959. The starting fullback at the beginning of the season was the senior, and Heisman Trophy candidate, Bob White. Through the course of the season, however, Ferguson supplanted White as the starter and led the team in rushing that season, averaging 6.1 yards per carry.
Ferguson finished his career at Ohio State with 2,162 rushing yards. This rushing total was at the time second in team history behind Howard "Hopalong" Cassady. Ferguson owns the distinction of never having been thrown for a loss during his college football career. Ferguson was inducted into the College Football Hall of Fame in 1996, and into Ohio State's own Varsity O Hall of Fame in 1987. He was selected to the Ohio State Football All-Century Team in 2000.
Ferguson returned to Ohio State and earned a master's degree in sociology. He worked as a youth counselor in Columbus, Ohio until he was forced to retire in 1990 due to health problems. Ferguson died in 2004 of complications due to diabetes.