Bombesin-like receptor 3

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Bombesin-like receptor 3
Identifiers
Symbols BRS3 ; BB3
External IDs OMIM300107 MGI1100501 HomoloGene1307 IUPHAR: BB3 ChEMBL: 4080 GeneCards: BRS3 Gene
RNA expression pattern
PBB GE BRS3 207369 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 680 12209
Ensembl ENSG00000102239 ENSMUSG00000031130
UniProt P32247 O54798
RefSeq (mRNA) NM_001727 NM_009766
RefSeq (protein) NP_001718 NP_033896
Location (UCSC) Chr X:
135.57 – 135.58 Mb
Chr X:
57.04 – 57.05 Mb
PubMed search [1] [2]

The bombesin receptor subtype 3 also known as BRS-3 or BB3[1] is a protein which in humans is encoded by the BRS3 gene.[2][3]

Function[edit]

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[3][4]

BB3 is a G protein-coupled receptor.[2] BB3 only interacts with known naturally-occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[2][5][6]

References[edit]

  1. ^ "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  2. ^ a b c Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. 
  3. ^ a b Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1-2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170. 
  4. ^ "Entrez Gene: BRS3 bombesin-like receptor 3". 
  5. ^ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH and Jensen RT. (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors.". J. Biol. Chem. 272 (41): 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344. 
  6. ^ Jensen RT, Battey JF, Spindel ER and Benya RV. (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states.". Pharmacol. Rev. 60 (1): 1–42. doi:10.1124/pr.107.07108. PMC 2517428. PMID 18055507. 

Further reading[edit]

External links[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.