Pomponius implied he was homosexual and referred to his "perverted habits". The homo-erotic verses (including one addressed to the then Bishop of Segni, Lucio Fazini) which were found in his papers, while earning him a reputation as a sodomite, seem to have been restricted to his youth. And this seems to have reflected the aims of the Rome Academy to revive the concept of homosexual love as the ideal, drawing on the precedents set by antiquity. But Buonaccorsi seems to have been particularly active within the group in writing about sexual infatuation between men. However, later once in Poland he seems to have turned his attention to heterosexual love instead; perhaps a cautious reaction to the violent events in Rome.
Buonaccorsi later became tutor to the sons of Polish King Casimir IV Jagiellon and took part in diplomatic missions. In 1474 he was named royal secretary, in 1476 he served as ambassador to Constantinople, and in 1486 he became the King's representative in Venice. With the accession to the Polish throne of Buonaccorsi's former pupil as John I of Poland, his influence peaked.