Bone morphogenetic protein 15

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Bone morphogenetic protein 15
Symbols BMP15 ; GDF9B; ODG2; POF4
External IDs OMIM300247 MGI1316745 HomoloGene3977 GeneCards: BMP15 Gene
RNA expression pattern
PBB GE BMP15 221332 at tn.png
More reference expression data
Species Human Mouse
Entrez 9210 12155
Ensembl ENSG00000130385 ENSMUSG00000023279
UniProt O95972 Q9Z0L4
RefSeq (mRNA) NM_005448 NM_009757
RefSeq (protein) NP_005439 NP_033887
Location (UCSC) Chr X:
50.91 – 50.92 Mb
Chr X:
6.31 – 6.32 Mb
PubMed search [1] [2]

Bone morphogenetic protein 15 is a protein that in humans is encoded by the BMP15 gene.[1][2] It's mainly involved in folliculogenesis.[3]

Structure and expression[edit]

The protein encoded by this gene is a member of the TGF-β superfamily. It is a paracrine signaling molecule involved in oocyte and follicular development. Using Northern blot analysis, BMP15 has been shown to be exclusively expressed in the ovaries. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.[2]


The functions of BMP15 include:[3]

Defects in BMP15 are associated with primary ovarian insufficiency. BMP15may represent a biomarker of ovarian response to ovarian stimulation or oocyte quality.[3]


  1. ^ Dube JL, Wang P, Elvin J, Lyons KM, Celeste AJ, Matzuk MM (Feb 1999). "The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes". Mol Endocrinol 12 (12): 1809–17. doi:10.1210/me.12.12.1809. PMID 9849956. 
  2. ^ a b "Entrez Gene: BMP15 bone morphogenetic protein 15". 
  3. ^ a b c Persani, L.; Rossetti, R.; Di Pasquale, E.; Cacciatore, C.; Fabre, S. (2014). "The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders". Human Reproduction Update 20 (6): 869–883. doi:10.1093/humupd/dmu036. ISSN 1355-4786. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.