Bone morphogenetic protein 3

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Not to be confused with BMP-3. ‹See Tfd›
Bone morphogenetic protein 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BMP3 ; BMP-3A
External IDs OMIM112263 MGI88179 HomoloGene927 GeneCards: BMP3 Gene
RNA expression pattern
PBB GE BMP3 208244 at tn.png
More reference expression data
Species Human Mouse
Entrez 651 110075
Ensembl ENSG00000152785 ENSMUSG00000029335
UniProt P12645 Q8BHE5
RefSeq (mRNA) NM_001201 NM_173404
RefSeq (protein) NP_001192 NP_775580
Location (UCSC) Chr 4:
81.95 – 81.98 Mb
Chr 5:
98.85 – 98.88 Mb
PubMed search [1] [2]

Bone morphogenetic protein 3 is a protein in humans that is encoded by the BMP3 gene.[1]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.

It is highly expressed in fractured tissues.


Further reading[edit]