Bone morphogenetic protein 3

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Not to be confused with BMP-3. ‹See Tfd›
Bone morphogenetic protein 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BMP3 ; BMP-3A
External IDs OMIM112263 MGI88179 HomoloGene927 GeneCards: BMP3 Gene
RNA expression pattern
PBB GE BMP3 208244 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 651 110075
Ensembl ENSG00000152785 ENSMUSG00000029335
UniProt P12645 Q8BHE5
RefSeq (mRNA) NM_001201 NM_173404
RefSeq (protein) NP_001192 NP_775580
Location (UCSC) Chr 4:
81.95 – 81.98 Mb
Chr 5:
98.85 – 98.88 Mb
PubMed search [1] [2]

Bone morphogenetic protein 3 is a protein in humans that is encoded by the BMP3 gene.[1]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.

It is highly expressed in fractured tissues.

References[edit]

Further reading[edit]