Bone morphogenetic protein 3

Not to be confused with BMP-3.

Bone morphogenetic protein 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2QCQ
Identifiers
Symbols	BMP3; BMP-3A
External IDs	OMIM: 112263 MGI: 88179 HomoloGene: 927 GeneCards: BMP3 Gene
Gene Ontology Molecular function • receptor binding • cytokine activity • growth factor activity • BMP receptor binding Cellular component • extracellular space Biological process • skeletal system development • ossification • cell-cell signaling • cell differentiation • growth • positive regulation of transcription from RNA polymerase II promoter • cartilage development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	651	110075
Ensembl	ENSG00000152785	ENSMUSG00000029335
UniProt	P12645	Q8BHE5
RefSeq (mRNA)	NM_001201	NM_173404
RefSeq (protein)	NP_001192	NP_775580
Location (UCSC)	Chr 4: 81.95 – 81.98 Mb	Chr 5: 98.85 – 98.88 Mb
PubMed search	[1]	[2]

Bone morphogenetic protein 3 is a protein in humans that is encoded by the BMP3 gene.

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.

It is highly expressed in fractured tissues.

Further reading

• Dickinson ME, Kobrin MS, Silan CM et al. (1990). "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci". Genomics 6 (3): 505–20. doi:10.1016/0888-7543(90)90480-I. PMID 1970330. 
• Tabas JA, Zasloff M, Wasmuth JJ et al. (1991). "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3". Genomics 9 (2): 283–9. doi:10.1016/0888-7543(91)90254-C. PMID 2004778. 
• Paralkar VM, Nandedkar AK, Pointer RH et al. (1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". J. Biol. Chem. 265 (28): 17281–4. PMID 2211625. 
• Rosen V, Wozney JM, Wang EA et al. (1990). "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone". Connect. Tissue Res. 20 (1–4): 313–9. doi:10.3109/03008208909023902. PMID 2612162. 
• Wozney JM, Rosen V, Celeste AJ et al. (1989). "Novel regulators of bone formation: molecular clones and activities". Science 242 (4885): 1528–34. doi:10.1126/science.3201241. PMID 3201241. 
• Faucheux C, Ulysse F, Bareille R et al. (1998). "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochem. Biophys. Res. Commun. 241 (3): 787–93. doi:10.1006/bbrc.1997.7792. PMID 9434787. 
• Daluiski A, Engstrand T, Bahamonde ME et al. (2001). "Bone morphogenetic protein-3 is a negative regulator of bone density". Nat. Genet. 27 (1): 84–8. doi:10.1038/83810. PMID 11138004. 
• Jin Y, Lu HB, Liong E et al. (2002). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histol. Histopathol. 16 (4): 1013–9. PMID 11642720. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Kloen P, Di Paola M, Borens O et al. (2004). "BMP signaling components are expressed in human fracture callus". Bone 33 (3): 362–71. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778. 
• Kang Q, Sun MH, Cheng H et al. (2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Ther. 11 (17): 1312–20. doi:10.1038/sj.gt.3302298. PMID 15269709. 
• Chen AL, Fang C, Liu C et al. (2004). "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage". J. Orthop. Res. 22 (6): 1188–92. doi:10.1016/j.orthres.2004.02.013. PMID 15475196. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.